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Excess of metalloproteases over tissue inhibitor of metalloprotease may contribute to cartilage degradation in osteoarthritis and rheumatoid arthritis.
Martel-Pelletier J, McCollum R, Fujimoto N, Obata K, Cloutier JM, Pelletier JP. Martel-Pelletier J, et al. Among authors: cloutier jm. Lab Invest. 1994 Jun;70(6):807-15. Lab Invest. 1994. PMID: 8015285
Proteoglycan-degrading acid metalloprotease activity in human osteoarthritic cartilage, and the effect of intraarticular steroid injections.
Pelletier JP, Martel-Pelletier J, Cloutier JM, Woessner JF Jr. Pelletier JP, et al. Among authors: cloutier jm. Arthritis Rheum. 1987 May;30(5):541-8. doi: 10.1002/art.1780300508. Arthritis Rheum. 1987. PMID: 3297073
In vivo effects of antirheumatic drugs on neutral collagenolytic proteases in human rheumatoid arthritis cartilage and synovium.
Martel-Pelletier J, Cloutier JM, Pelletier JP. Martel-Pelletier J, et al. Among authors: cloutier jm. J Rheumatol. 1988 Aug;15(8):1198-204. J Rheumatol. 1988. PMID: 3054093
Normal expression of type 1 insulin-like growth factor receptor by human osteoarthritic chondrocytes with increased expression and synthesis of insulin-like growth factor binding proteins.
Tardif G, Reboul P, Pelletier JP, Geng C, Cloutier JM, Martel-Pelletier J. Tardif G, et al. Among authors: cloutier jm. Arthritis Rheum. 1996 Jun;39(6):968-78. doi: 10.1002/art.1780390614. Arthritis Rheum. 1996. PMID: 8651991
Increased insulin-like growth factor 1 production by human osteoarthritic chondrocytes is not dependent on growth hormone action.
Doré S, Abribat T, Rousseau N, Brazeau P, Tardif G, DiBattista JA, Cloutier JM, Pelletier JP, Martel-Pelletier J. Doré S, et al. Among authors: cloutier jm. Arthritis Rheum. 1995 Mar;38(3):413-9. doi: 10.1002/art.1780380319. Arthritis Rheum. 1995. PMID: 7880196
Differential effects of IL-8, LIF (pro-inflammatory) and IL-11 (anti-inflammatory) on TNF-alpha-induced PGE(2)release and on signalling pathways in human OA synovial fibroblasts.
Alaaeddine N, Di Battista JA, Pelletier JP, Kiansa K, Cloutier JM, Martel-Pelletier J. Alaaeddine N, et al. Among authors: cloutier jm. Cytokine. 1999 Dec;11(12):1020-30. doi: 10.1006/cyto.1999.0505. Cytokine. 1999. PMID: 10623427
Collagenase 3 production by human osteoarthritic chondrocytes in response to growth factors and cytokines is a function of the physiologic state of the cells.
Tardif G, Pelletier JP, Dupuis M, Geng C, Cloutier JM, Martel-Pelletier J. Tardif G, et al. Among authors: cloutier jm. Arthritis Rheum. 1999 Jun;42(6):1147-58. doi: 10.1002/1529-0131(199906)42:6<1147::AID-ANR11>3.0.CO;2-Y. Arthritis Rheum. 1999. PMID: 10366107
Distinct expression pattern of early- and late-response genes in normal and osteoarthritic human synovial membranes.
Zafarullah M, Martel-Pelletier J, Cloutier JM, Gedamu L, Pelletier JP. Zafarullah M, et al. Among authors: cloutier jm. Osteoarthritis Cartilage. 1993 Jul;1(3):151-6. doi: 10.1016/s1063-4584(05)80085-8. Osteoarthritis Cartilage. 1993. PMID: 15449420
Modulation of collagenase 3 in human osteoarthritic cartilage by activation of extracellular transforming growth factor beta: role of furin convertase.
Moldovan F, Pelletier JP, Mineau F, Dupuis M, Cloutier JM, Martel-Pelletier J. Moldovan F, et al. Among authors: cloutier jm. Arthritis Rheum. 2000 Sep;43(9):2100-9. doi: 10.1002/1529-0131(200009)43:9<2100::AID-ANR22>3.0.CO;2-#. Arthritis Rheum. 2000. PMID: 11014362
Diacerhein and rhein reduce the ICE-induced IL-1beta and IL-18 activation in human osteoarthritic cartilage.
Moldovan F, Pelletier JP, Jolicoeur FC, Cloutier JM, Martel-Pelletier J. Moldovan F, et al. Among authors: cloutier jm. Osteoarthritis Cartilage. 2000 May;8(3):186-96. doi: 10.1053/joca.1999.0289. Osteoarthritis Cartilage. 2000. PMID: 10806046
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