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Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.
Nature. 2018 Mar 1;555(7694):121-125. doi: 10.1038/nature25773. Epub 2018 Feb 21.
Nature. 2018.
PMID: 29466332
Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1.
Hager MV, Clydesdale L, Gellman SH, Sexton PM, Wootten D.
Hager MV, et al. Among authors: clydesdale l.
Biochem Pharmacol. 2017 Jul 15;136:99-108. doi: 10.1016/j.bcp.2017.03.018. Epub 2017 Mar 29.
Biochem Pharmacol. 2017.
PMID: 28363772
Free PMC article.
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Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism.
Lei S, Clydesdale L, Dai A, Cai X, Feng Y, Yang D, Liang YL, Koole C, Zhao P, Coudrat T, Christopoulos A, Wang MW, Wootten D, Sexton PM.
Lei S, et al. Among authors: clydesdale l.
J Biol Chem. 2018 Jun 15;293(24):9370-9387. doi: 10.1074/jbc.RA118.003278. Epub 2018 May 1.
J Biol Chem. 2018.
PMID: 29717000
Free PMC article.
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Activation of the GLP-1 receptor by a non-peptidic agonist.
Zhao P, Liang YL, Belousoff MJ, Deganutti G, Fletcher MM, Willard FS, Bell MG, Christe ME, Sloop KW, Inoue A, Truong TT, Clydesdale L, Furness SGB, Christopoulos A, Wang MW, Miller LJ, Reynolds CA, Danev R, Sexton PM, Wootten D.
Zhao P, et al. Among authors: clydesdale l.
Nature. 2020 Jan;577(7790):432-436. doi: 10.1038/s41586-019-1902-z. Epub 2020 Jan 8.
Nature. 2020.
PMID: 31915381
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Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation.
Deganutti G, Liang YL, Zhang X, Khoshouei M, Clydesdale L, Belousoff MJ, Venugopal H, Truong TT, Glukhova A, Keller AN, Gregory KJ, Leach K, Christopoulos A, Danev R, Reynolds CA, Zhao P, Sexton PM, Wootten D.
Deganutti G, et al. Among authors: clydesdale l.
Nat Commun. 2022 Jan 10;13(1):92. doi: 10.1038/s41467-021-27760-0.
Nat Commun. 2022.
PMID: 35013280
Free PMC article.
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Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists.
Fletcher MM, Halls ML, Zhao P, Clydesdale L, Christopoulos A, Sexton PM, Wootten D.
Fletcher MM, et al. Among authors: clydesdale l.
Biochem Pharmacol. 2018 Oct;156:406-419. doi: 10.1016/j.bcp.2018.09.003. Epub 2018 Sep 7.
Biochem Pharmacol. 2018.
PMID: 30195733
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