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A genomic atlas of systemic interindividual epigenetic variation in humans.
Gunasekara CJ, Scott CA, Laritsky E, Baker MS, MacKay H, Duryea JD, Kessler NJ, Hellenthal G, Wood AC, Hodges KR, Gandhi M, Hair AB, Silver MJ, Moore SE, Prentice AM, Li Y, Chen R, Coarfa C, Waterland RA. Gunasekara CJ, et al. Genome Biol. 2019 Jun 3;20(1):105. doi: 10.1186/s13059-019-1708-1. Genome Biol. 2019. PMID: 31155008 Free PMC article.
This approach identifies 9926 correlated regions of systemic interindividual variation (CoRSIVs). These regions, comprising just 0.1% of the human genome, are inter-correlated over long genomic distances, associated with transposable elements and subtelomeric regions, cons …
This approach identifies 9926 correlated regions of systemic interindividual variation (CoRSIVs). These regions, comprising just 0.1% …
Perfluorooctanoic acid (PFOA) or perfluorooctane sulfonate (PFOS) and DNA methylation in newborn dried blood spots in the Upstate KIDS cohort.
Robinson SL, Zeng X, Guan W, Sundaram R, Mendola P, Putnick DL, Waterland RA, Gunasekara CJ, Kannan K, Gao C, Bell EM, Yeung EH. Robinson SL, et al. Environ Res. 2021 Mar;194:110668. doi: 10.1016/j.envres.2020.110668. Epub 2020 Dec 30. Environ Res. 2021. PMID: 33387539
In supplemental analysis, we restricted the analysis to 2242 CpG sites previously identified as Correlated Regions of Systemic Interindividual Variation (CoRSIVs) which include metastable epialleles. At FDR<0.05, PFOA concentration >90th percentile was related to DNA …
In supplemental analysis, we restricted the analysis to 2242 CpG sites previously identified as Correlated Regions of Systemic Interindividu …