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The future challenges facing the development of new antimicrobial drugs.
Coates A, Hu Y, Bax R, Page C. Coates A, et al. Nat Rev Drug Discov. 2002 Nov;1(11):895-910. doi: 10.1038/nrd940. Nat Rev Drug Discov. 2002. PMID: 12415249 Review.
The emergence of resistance to antibacterial agents is a pressing concern for human health. New drugs to combat this problem are therefore in great demand, but as past experience indicates, the time for resistance to new drugs to develop is often short. ...
The emergence of resistance to antibacterial agents is a pressing concern for human health. New drugs to combat this problem are ther …
The Mycobacterium tuberculosis sigJ gene controls sensitivity of the bacterium to hydrogen peroxide.
Hu Y, Kendall S, Stoker NG, Coates AR. Hu Y, et al. FEMS Microbiol Lett. 2004 Aug 15;237(2):415-23. doi: 10.1016/j.femsle.2004.07.005. FEMS Microbiol Lett. 2004. PMID: 15321691
In order to verify the function of SigJ, we constructed a Mycobacterium tuberculosis mutant lacking the sigJ gene. In a microaerophilic stationary-phase model, the sigJ mutant showed the same growth pattern as the wild-type strain. In an immune stasis murine model i …
In order to verify the function of SigJ, we constructed a Mycobacterium tuberculosis mutant lacking the sigJ gene. In a microa …
Predictive in vitro models of the sterilizing activity of anti-tuberculosis drugs.
Mitchison DA, Coates AR. Mitchison DA, et al. Curr Pharm Des. 2004;10(26):3285-95. doi: 10.2174/1381612043383269. Curr Pharm Des. 2004. PMID: 15544516 Review.
After re-suspension in rifampicin-free liquid medium for 7 days, the bacilli recover growth on solid medium, when a colony count is done. ...
After re-suspension in rifampicin-free liquid medium for 7 days, the bacilli recover growth on solid medium, when a colony count is d …
Transposon mutagenesis identifies genes which control antimicrobial drug tolerance in stationary-phase Escherichia coli.
Hu Y, Coates AR. Hu Y, et al. FEMS Microbiol Lett. 2005 Feb 1;243(1):117-24. doi: 10.1016/j.femsle.2004.11.049. FEMS Microbiol Lett. 2005. PMID: 15668009
Tolerance to antimicrobial agents is a universal phenomenon in bacteria which are no longer multiplying or whose growth rate slows. ...Furthermore, they show that it is important in murine infection during antibiotic treatment and lead to a faster kill of the mutant …
Tolerance to antimicrobial agents is a universal phenomenon in bacteria which are no longer multiplying or whose growth rate slows. . …
New strategies for antibacterial drug design: targeting non-multiplying latent bacteria.
Coates AR, Hu Y. Coates AR, et al. Drugs R D. 2006;7(3):133-51. doi: 10.2165/00126839-200607030-00001. Drugs R D. 2006. PMID: 16752940 Review.
New antibacterials are needed to replace those that have become less effective as a result of the emergence of a high level of resistance amongst target bacteria. ...Bacteria in such a phase are much more tolerant to antibacterials than logarithmic phase orga …
New antibacterials are needed to replace those that have become less effective as a result of the emergence of a high level of …
Targeting non-multiplying organisms as a way to develop novel antimicrobials.
Coates AR, Hu Y. Coates AR, et al. Trends Pharmacol Sci. 2008 Mar;29(3):143-50. doi: 10.1016/j.tips.2007.12.001. Epub 2008 Feb 11. Trends Pharmacol Sci. 2008. PMID: 18262665 Review.
Increasing resistance and decreasing numbers of antibiotics reaching the market point to a growing need for novel antibacterial drugs. Most antibiotics are very inefficient at killing non-multiplying bacteria, which live side by side with multiplying ones of the same strai …
Increasing resistance and decreasing numbers of antibiotics reaching the market point to a growing need for novel antibacterial drugs …
Nasal decolonization of Staphylococcus aureus with mupirocin: strengths, weaknesses and future prospects.
Coates T, Bax R, Coates A. Coates T, et al. J Antimicrob Chemother. 2009 Jul;64(1):9-15. doi: 10.1093/jac/dkp159. Epub 2009 May 18. J Antimicrob Chemother. 2009. PMID: 19451132 Free PMC article. Review.
Mupirocin is effective at removing S. aureus from the nose over a few weeks, but relapses are common within several months. There are only a few prospective randomized clinical trials that have been completed with sufficient patients, but those that have been report …
Mupirocin is effective at removing S. aureus from the nose over a few weeks, but relapses are common within several months. There are …
A new approach for the discovery of antibiotics by targeting non-multiplying bacteria: a novel topical antibiotic for staphylococcal infections.
Hu Y, Shamaei-Tousi A, Liu Y, Coates A. Hu Y, et al. PLoS One. 2010 Jul 27;5(7):e11818. doi: 10.1371/journal.pone.0011818. PLoS One. 2010. PMID: 20676403 Free PMC article.
The antibiotic, called HT61, is a small quinolone-derived compound with a molecular mass of about 400 Daltons, and is active against non-multiplying bacteria, including methicillin sensitive and resistant, as well as Panton-Valentine leukocidin-carrying Staphylococc …
The antibiotic, called HT61, is a small quinolone-derived compound with a molecular mass of about 400 Daltons, and is active a …
Novel classes of antibiotics or more of the same?
Coates AR, Halls G, Hu Y. Coates AR, et al. Br J Pharmacol. 2011 May;163(1):184-94. doi: 10.1111/j.1476-5381.2011.01250.x. Br J Pharmacol. 2011. PMID: 21323894 Free PMC article. Review.
Only a huge effort by governments in the form of finance, legislation and providing industry with real incentives will reverse this. Industry needs to re-enter the market on a much larger scale, and academia should rebuild its antibiotic discovery infrastructure to …
Only a huge effort by governments in the form of finance, legislation and providing industry with real incentives will reverse this. …
HPLC/MS/MS methodology for sensitive quantitation of monic acid A, the metabolic product of the antibiotic mupirocin.
Haidar EA, Lee TD, Barton JD, Coates AR, Mantle PG. Haidar EA, et al. Biomarkers. 2011 Aug;16(5):422-5. doi: 10.3109/1354750X.2011.582153. Epub 2011 May 20. Biomarkers. 2011. PMID: 21595607
Herein, we describe a potential methodology for assessing adherence by measuring the gastric degradation product, monic acid A (MA), as a biomarker in urine. MA was isolated (~80% recovery) through a Waters Oasis HLB cartridge and detected (e.g. 25 pg …
Herein, we describe a potential methodology for assessing adherence by measuring the gastric degradation product, monic acid A
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