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A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target.
He C, Nora GP, Schneider EL, Kerr ID, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd SE, Hruz P, Cobo ER, Le C, Liu WT, Eckmann L, Dorrestein PC, Houpt ER, Brinen LS, Craik CS, Roush WR, McKerrow J, Reed SL. He C, et al. Among authors: cobo er. J Biol Chem. 2010 Jun 11;285(24):18516-27. doi: 10.1074/jbc.M109.086181. Epub 2010 Apr 8. J Biol Chem. 2010. PMID: 20378535 Free PMC article.
A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target.
Debnath A, Parsonage D, Andrade RM, He C, Cobo ER, Hirata K, Chen S, García-Rivera G, Orozco E, Martínez MB, Gunatilleke SS, Barrios AM, Arkin MR, Poole LB, McKerrow JH, Reed SL. Debnath A, et al. Among authors: cobo er. Nat Med. 2012 Jun;18(6):956-60. doi: 10.1038/nm.2758. Nat Med. 2012. PMID: 22610278 Free PMC article.
Murine models of vaginal trichomonad infections.
Cobo ER, Eckmann L, Corbeil LB. Cobo ER, et al. Am J Trop Med Hyg. 2011 Oct;85(4):667-73. doi: 10.4269/ajtmh.2011.11-0123. Am J Trop Med Hyg. 2011. PMID: 21976570 Free PMC article.
Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity.
Miyamoto Y, Kalisiak J, Korthals K, Lauwaet T, Cheung DY, Lozano R, Cobo ER, Upcroft P, Upcroft JA, Berg DE, Gillin FD, Fokin VV, Sharpless KB, Eckmann L. Miyamoto Y, et al. Among authors: cobo er. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17564-9. doi: 10.1073/pnas.1302664110. Epub 2013 Oct 7. Proc Natl Acad Sci U S A. 2013. PMID: 24101497 Free PMC article.
63 results