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Page 1
Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss.
Trpchevska N, Freidin MB, Broer L, Oosterloo BC, Yao S, Zhou Y, Vona B, Bishop C, Bizaki-Vallaskangas A, Canlon B, Castellana F, Chasman DI, Cherny S, Christensen K, Concas MP, Correa A, Elkon R; Estonian Biobank Research Team; Mengel-From J, Gao Y, Giersch ABS, Girotto G, Gudjonsson A, Gudnason V, Heard-Costa NL, Hertzano R, Hjelmborg JVB, Hjerling-Leffler J, Hoffman HJ, Kaprio J, Kettunen J, Krebs K, Kähler AK, Lallemend F, Launer LJ, Lee IM, Leonard H, Li CM, Lowenheim H, Magnusson PKE, van Meurs J, Milani L, Morton CC, Mäkitie A, Nalls MA, Nardone GG, Nygaard M, Palviainen T, Pratt S, Quaranta N, Rämö J, Saarentaus E, Sardone R, Satizabal CL, Schweinfurth JM, Seshadri S, Shiroma E, Shulman E, Simonsick E, Spankovich C, Tropitzsch A, Lauschke VM, Sullivan PF, Goedegebure A, Cederroth CR, Williams FMK, Nagtegaal AP. Trpchevska N, et al. Am J Hum Genet. 2022 Jun 2;109(6):1077-1091. doi: 10.1016/j.ajhg.2022.04.010. Epub 2022 May 16. Am J Hum Genet. 2022. PMID: 35580588 Free PMC article.
We used single-cell RNA-sequencing data from mouse cochlea and brain and mapped common-variant genomic results to spindle, root, and basal cells from the stria vascularis, a structure in the cochlea necessary for normal hearing. ...
We used single-cell RNA-sequencing data from mouse cochlea and brain and mapped common-variant genomic results to spindle, root, and …
Genetic Hearing Loss Associated With Autoinflammation.
Nakanishi H, Prakash P, Ito T, Kim HJ, Brewer CC, Harrow D, Roux I, Hosokawa S, Griffith AJ. Nakanishi H, et al. Front Neurol. 2020 Mar 5;11:141. doi: 10.3389/fneur.2020.00141. eCollection 2020. Front Neurol. 2020. PMID: 32194497 Free PMC article. Review.
These observations led us to test the hypothesis that macrophage/monocyte-like cells in the cochlea can mediate local autoinflammation via activation of the NLRP3 inflammasome. The inflammasome can indeed be activated in macrophage/monocyte-like cells of the mouse cochl …
These observations led us to test the hypothesis that macrophage/monocyte-like cells in the cochlea can mediate local autoinflammatio …
Patient-Reported Outcomes After Vestibular Implantation for Bilateral Vestibular Hypofunction.
Ayiotis AI, Schoo DP, Fernandez Brillet C, Lane KE, Carey JP, Della Santina CC. Ayiotis AI, et al. JAMA Otolaryngol Head Neck Surg. 2024 Mar 1;150(3):240-248. doi: 10.1001/jamaoto.2023.4475. JAMA Otolaryngol Head Neck Surg. 2024. PMID: 38300591 Free PMC article.
INTERVENTION: The MVI system electrically stimulates semicircular canal branches of the vestibular nerve to convey head rotation. MAIN OUTCOMES AND MEASURES: Patient-reported outcome instruments assessing dizziness (Dizziness Handicap Inventory [DHI]) and vestibular-relate …
INTERVENTION: The MVI system electrically stimulates semicircular canal branches of the vestibular nerve to convey head rotation. MAI …
Single Cell Sequencing of the Pineal Gland: The Next Chapter.
Coon SL, Fu C, Hartley SW, Holtzclaw L, Mays JC, Kelly MC, Kelley MW, Mullikin JC, Rath MF, Savastano LE, Klein DC. Coon SL, et al. Front Endocrinol (Lausanne). 2019 Sep 20;10:590. doi: 10.3389/fendo.2019.00590. eCollection 2019. Front Endocrinol (Lausanne). 2019. PMID: 31616371 Free PMC article. Review.
Dissection of the Endolymphatic Sac from Mice.
Honda K, Lee HJ, Griffith AJ, Roux I. Honda K, et al. J Vis Exp. 2021 Mar 29;(169):10.3791/62375. doi: 10.3791/62375. J Vis Exp. 2021. PMID: 33843930 Free PMC article.
Although important progress has been done in the understanding of the development and function of the neurosensory epithelia of the cochlea and vestibula, limited knowledge is available regarding the development, cellular composition, molecular pathways and functional char …
Although important progress has been done in the understanding of the development and function of the neurosensory epithelia of the cochl …
Cyclodextrins and Iatrogenic Hearing Loss: New Drugs with Significant Risk.
Crumling MA, King KA, Duncan RK. Crumling MA, et al. Front Cell Neurosci. 2017 Nov 8;11:355. doi: 10.3389/fncel.2017.00355. eCollection 2017. Front Cell Neurosci. 2017. PMID: 29163061 Free PMC article. Review.
Ototoxicity can occur following central or peripheral drug delivery, with either route resulting in the preferential loss of cochlear outer hair cells (OHCs) within hours of dosing. Inner hair cells and spiral ganglion cells are spared at doses that cause ~85% OHC loss; ad …
Ototoxicity can occur following central or peripheral drug delivery, with either route resulting in the preferential loss of cochlear …
Olivocochlear projections contribute to superior intensity coding in cochlear nucleus small cells.
Hockley A, Wu C, Shore SE. Hockley A, et al. J Physiol. 2022 Jan;600(1):61-73. doi: 10.1113/JP282262. Epub 2021 Dec 6. J Physiol. 2022. PMID: 34761815 Free PMC article.
Understanding communication signals, especially in noisy environments, is crucial to social interactions. Yet, as we age, acoustic signals can be disrupted by cochlear damage and the subsequent auditory nerve fibre degeneration. The most vulnerable medium- and high- …
Understanding communication signals, especially in noisy environments, is crucial to social interactions. Yet, as we age, acoustic si …
Metformin Protects Against Noise-Induced Hearing Loss in Male Mice.
Kennedy CL, Shuster B, Amanipour R, Milon B, Patel P, Elkon R, Hertzano R. Kennedy CL, et al. Otol Neurotol. 2023 Oct 1;44(9):956-963. doi: 10.1097/MAO.0000000000004002. Epub 2023 Aug 29. Otol Neurotol. 2023. PMID: 37641232 Free PMC article.

After the 1-week ABR, mice were euthanized and cochlear tissue was analyzed. RESULTS: Metformin treatment reduced the 1-week ABR threshold shift at 16 kHz ( p < 0.01; d = 1.20) and 24 kHz ( p < 0.01; d = 1.15) as well as outer hair cell loss in the 32-45.5 kHz range

…
After the 1-week ABR, mice were euthanized and cochlear tissue was analyzed. RESULTS: Metformin treatment reduced the 1-week ABR thre …
AAV8BP2 and AAV8 transduce the mammalian cochlear lateral wall and endolymphatic sac with high efficiency.
Isgrig K, Ishibashi Y, Lee HJ, Zhu J, Grati M, Bennett J, Griffith AJ, Roux I, Chien WW. Isgrig K, et al. Mol Ther Methods Clin Dev. 2022 Jul 31;26:371-383. doi: 10.1016/j.omtm.2022.07.013. eCollection 2022 Sep 8. Mol Ther Methods Clin Dev. 2022. PMID: 36034771 Free PMC article.
While most inner ear gene therapy studies have focused on the mechanosensory hair cells and supporting cells in the organ of Corti, the cochlear lateral wall and the endolymphatic sac have not garnered much attention. The cochlear lateral wall and the endolymphatic …
While most inner ear gene therapy studies have focused on the mechanosensory hair cells and supporting cells in the organ of Corti, the c …
69 results