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Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models.
Rondeau V, Berman JM, Ling T, O'Brien C, Culp-Hill R, Reisz JA, Wunderlich M, Chueh Y, Jiménez-Camacho KE, Sexton C, Carter KM, Stillwell C, St-Germain J, Yendi D, Gupta A, Shi M, Bourdine A, Paralkar VR, Jahangiri S, Hope KJ, Tikhonova AN, Arruda A, Minden MD, Raught B, D'Alessandro A, Jones CL. Rondeau V, et al. Among authors: stillwell c. Sci Transl Med. 2024 Sep 25;16(766):eadn1285. doi: 10.1126/scitranslmed.adn1285. Epub 2024 Sep 25. Sci Transl Med. 2024. PMID: 39321266 Free PMC article.
Pyrimidine depletion enhances targeted and immune therapy combinations in acute myeloid leukemia.
Elgamal OA, Fobare S, Vibhute S, Mehmood A, Vroom DC, Johnson ML, Stearns B, Lerma JR, Truxall J, Stahl E, Carmichael B, Orwick SJ, Mims AS, Curran E, Santhanam R, Tridandapani S, Phelps MA, Xie Z, Coss CC, Baker SD, Patrick J, Ezzell JK, Rai J, Pan J, Rai SN, Stillwell C, Wunderlich M, Abdulrahim M, Goodwin TE, Hilinski G, Bennett CE, Hertlein E, Byrd JC. Elgamal OA, et al. Among authors: stillwell c. JCI Insight. 2024 Apr 22;9(8):e173646. doi: 10.1172/jci.insight.173646. JCI Insight. 2024. PMID: 38646934 Free PMC article.
Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation.
Ling T, O'Brien C, St-Germain J, Rondeau V, Shi M, Berman JM, Cepa AK, Saez Raez P, Wunderlich M, Carter K, Stillwell C, Sexton CR, Culp-Hill R, Reisz JA, Adeel SA, Zeng AGX, Bansal S, Tsao E, Chen HTT, Dick JE, Minden MD, Arruda A, Amaya ML, Tikhonova AN, Hope K, D'Alessandro A, Raught B, Jones CL. Ling T, et al. Among authors: stillwell c. Blood. 2025 Nov 14:blood.2025028933. doi: 10.1182/blood.2025028933. Online ahead of print. Blood. 2025. PMID: 41237364