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Mutations that increase DNA binding by the processivity factor of herpes simplex virus affect virus production and DNA replication fidelity.
Jiang C, Komazin-Meredith G, Tian W, Coen DM, Hwang CB. Jiang C, et al. Among authors: coen dm. J Virol. 2009 Aug;83(15):7573-80. doi: 10.1128/JVI.00193-09. Epub 2009 May 27. J Virol. 2009. PMID: 19474109 Free PMC article.
Role of homodimerization of human cytomegalovirus DNA polymerase accessory protein UL44 in origin-dependent DNA replication in cells.
Sinigalia E, Alvisi G, Mercorelli B, Coen DM, Pari GS, Jans DA, Ripalti A, Pal├╣ G, Loregian A. Sinigalia E, et al. Among authors: coen dm. J Virol. 2008 Dec;82(24):12574-9. doi: 10.1128/JVI.01193-08. Epub 2008 Oct 8. J Virol. 2008. PMID: 18842734 Free PMC article.
Expression of extremely low levels of thymidine kinase from an acyclovir-resistant herpes simplex virus mutant supports reactivation from latently infected mouse trigeminal ganglia.
Besecker MI, Furness CL, Coen DM, Griffiths A. Besecker MI, et al. Among authors: coen dm. J Virol. 2007 Aug;81(15):8356-60. doi: 10.1128/JVI.00484-07. Epub 2007 May 23. J Virol. 2007. PMID: 17522225 Free PMC article.
Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication.
Jiang C, Hwang YT, Randell JC, Coen DM, Hwang CB. Jiang C, et al. Among authors: coen dm. J Virol. 2007 Apr;81(7):3495-502. doi: 10.1128/JVI.02359-06. Epub 2007 Jan 17. J Virol. 2007. PMID: 17229696 Free PMC article.
Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection.
Cook WJ, Kramer MF, Walker RM, Burwell TJ, Holman HA, Coen DM, Knipe DM. Cook WJ, et al. Among authors: coen dm. Virol J. 2004 Sep 23;1:5. doi: 10.1186/1743-422X-1-5. Virol J. 2004. PMID: 15507126 Free PMC article.
Specific residues in the connector loop of the human cytomegalovirus DNA polymerase accessory protein UL44 are crucial for interaction with the UL54 catalytic subunit.
Loregian A, Appleton BA, Hogle JM, Coen DM. Loregian A, et al. Among authors: coen dm. J Virol. 2004 Sep;78(17):9084-92. doi: 10.1128/JVI.78.17.9084-9092.2004. J Virol. 2004. PMID: 15308704 Free PMC article.
ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells.
Bryant KF, Macari ER, Malik N, Boyce M, Yuan J, Coen DM. Bryant KF, et al. Among authors: coen dm. Virology. 2008 Sep 30;379(2):197-204. doi: 10.1016/j.virol.2008.06.028. Epub 2008 Aug 6. Virology. 2008. PMID: 18684481 Free PMC article.
Herpes simplex virus mutants with multiple substitutions affecting DNA binding of UL42 are impaired for viral replication and DNA synthesis.
Jiang C, Hwang YT, Wang G, Randell JC, Coen DM, Hwang CB. Jiang C, et al. Among authors: coen dm. J Virol. 2007 Nov;81(21):12077-9. doi: 10.1128/JVI.01133-07. Epub 2007 Aug 22. J Virol. 2007. PMID: 17715219 Free PMC article.
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