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266 results
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The discovery of HTLV-1, the first pathogenic human retrovirus.
Coffin JM. Coffin JM. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15525-9. doi: 10.1073/pnas.1521629112. Proc Natl Acad Sci U S A. 2015. PMID: 26696625 Free PMC article.
Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy.
Cillo AR, Sobolewski MD, Bosch RJ, Fyne E, Piatak M Jr, Coffin JM, Mellors JW. Cillo AR, et al. Among authors: coffin jm. Proc Natl Acad Sci U S A. 2014 May 13;111(19):7078-83. doi: 10.1073/pnas.1402873111. Epub 2014 Mar 31. Proc Natl Acad Sci U S A. 2014. PMID: 24706775 Free PMC article.
Majority of CD4+ T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA molecule.
Josefsson L, King MS, Makitalo B, Brännström J, Shao W, Maldarelli F, Kearney MF, Hu WS, Chen J, Gaines H, Mellors JW, Albert J, Coffin JM, Palmer SE. Josefsson L, et al. Among authors: coffin jm. Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11199-204. doi: 10.1073/pnas.1107729108. Epub 2011 Jun 20. Proc Natl Acad Sci U S A. 2011. PMID: 21690402 Free PMC article.
Likely role of APOBEC3G-mediated G-to-A mutations in HIV-1 evolution and drug resistance.
Jern P, Russell RA, Pathak VK, Coffin JM. Jern P, et al. Among authors: coffin jm. PLoS Pathog. 2009 Apr;5(4):e1000367. doi: 10.1371/journal.ppat.1000367. Epub 2009 Apr 3. PLoS Pathog. 2009. PMID: 19343218 Free PMC article.
Single-cell analysis of HIV-1 transcriptional activity reveals expression of proviruses in expanded clones during ART.
Wiegand A, Spindler J, Hong FF, Shao W, Cyktor JC, Cillo AR, Halvas EK, Coffin JM, Mellors JW, Kearney MF. Wiegand A, et al. Among authors: coffin jm. Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3659-E3668. doi: 10.1073/pnas.1617961114. Epub 2017 Apr 17. Proc Natl Acad Sci U S A. 2017. PMID: 28416661 Free PMC article.
What Integration Sites Tell Us about HIV Persistence.
Hughes SH, Coffin JM. Hughes SH, et al. Among authors: coffin jm. Cell Host Microbe. 2016 May 11;19(5):588-98. doi: 10.1016/j.chom.2016.04.010. Cell Host Microbe. 2016. PMID: 27173927 Free PMC article. Review.
Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo.
Simonetti FR, Sobolewski MD, Fyne E, Shao W, Spindler J, Hattori J, Anderson EM, Watters SA, Hill S, Wu X, Wells D, Su L, Luke BT, Halvas EK, Besson G, Penrose KJ, Yang Z, Kwan RW, Van Waes C, Uldrick T, Citrin DE, Kovacs J, Polis MA, Rehm CA, Gorelick R, Piatak M, Keele BF, Kearney MF, Coffin JM, Hughes SH, Mellors JW, Maldarelli F. Simonetti FR, et al. Among authors: coffin jm. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1883-8. doi: 10.1073/pnas.1522675113. Epub 2016 Feb 8. Proc Natl Acad Sci U S A. 2016. PMID: 26858442 Free PMC article.
Well-mixed plasma and tissue viral populations in RT-SHIV-infected macaques implies a lack of viral replication in the tissues during antiretroviral therapy.
Kearney MF, Anderson EM, Coomer C, Smith L, Shao W, Johnson N, Kline C, Spindler J, Mellors JW, Coffin JM, Ambrose Z. Kearney MF, et al. Among authors: coffin jm. Retrovirology. 2015 Nov 11;12:93. doi: 10.1186/s12977-015-0212-2. Retrovirology. 2015. PMID: 26559632 Free PMC article.
HIV-1 infection leads to increased transcription of human endogenous retrovirus HERV-K (HML-2) proviruses in vivo but not to increased virion production.
Bhardwaj N, Maldarelli F, Mellors J, Coffin JM. Bhardwaj N, et al. Among authors: coffin jm. J Virol. 2014 Oct;88(19):11108-20. doi: 10.1128/JVI.01623-14. Epub 2014 Jul 23. J Virol. 2014. PMID: 25056891 Free PMC article.
Fifteen years later: hard and soft selection sweeps confirm a large population number for HIV in vivo.
Rouzine IM, Coffin JM, Weinberger LS. Rouzine IM, et al. Among authors: coffin jm. PLoS Genet. 2014 Feb 20;10(2):e1004179. doi: 10.1371/journal.pgen.1004179. eCollection 2014 Feb. PLoS Genet. 2014. PMID: 24586204 Free PMC article. No abstract available.
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