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A Broad-Spectrum Inhibitor of CRISPR-Cas9.
Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA. Harrington LB, et al. Among authors: Cofsky JC. Cell. 2017 Sep 7;170(6):1224-1233.e15. doi: 10.1016/j.cell.2017.07.037. Epub 2017 Aug 24. Cell. 2017. PMID: 28844692 Free PMC article.
Deconstruction of the Ras switching cycle through saturation mutagenesis.
Bandaru P, Shah NH, Bhattacharyya M, Barton JP, Kondo Y, Cofsky JC, Gee CL, Chakraborty AK, Kortemme T, Ranganathan R, Kuriyan J. Bandaru P, et al. Among authors: Cofsky JC. Elife. 2017 Jul 7;6:e27810. doi: 10.7554/eLife.27810. Elife. 2017. PMID: 28686159 Free PMC article.
Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme.
Knott GJ, East-Seletsky A, Cofsky JC, Holton JM, Charles E, O'Connell MR, Doudna JA. Knott GJ, et al. Among authors: Cofsky JC. Nat Struct Mol Biol. 2017 Oct;24(10):825-833. doi: 10.1038/nsmb.3466. Epub 2017 Sep 11. Nat Struct Mol Biol. 2017. PMID: 28892041 Free PMC article.
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes.
Harrington LB, Burstein D, Chen JS, Paez-Espino D, Ma E, Witte IP, Cofsky JC, Kyrpides NC, Banfield JF, Doudna JA. Harrington LB, et al. Among authors: Cofsky JC. Science. 2018 Nov 16;362(6416):839-842. doi: 10.1126/science.aav4294. Epub 2018 Oct 18. Science. 2018. PMID: 30337455 Free PMC article.
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling.
Ivanov IE, Wright AV, Cofsky JC, Aris KDP, Doudna JA, Bryant Z. Ivanov IE, et al. Among authors: Cofsky JC. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):5853-5860. doi: 10.1073/pnas.1913445117. Epub 2020 Mar 2. Proc Natl Acad Sci U S A. 2020. PMID: 32123105 Free article.
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