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Prion protein biology.
Prusiner SB, Scott MR, DeArmond SJ, Cohen FE. Prusiner SB, et al. Cell. 1998 May 1;93(3):337-48. doi: 10.1016/s0092-8674(00)81163-0. Cell. 1998. PMID: 9590169 Review. No abstract available.
Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics.
May BC, Zorn JA, Witkop J, Sherrill J, Wallace AC, Legname G, Prusiner SB, Cohen FE. May BC, et al. J Med Chem. 2007 Jan 11;50(1):65-73. doi: 10.1021/jm061045z. J Med Chem. 2007. PMID: 17201410
Cell division modulates prion accumulation in cultured cells.
Ghaemmaghami S, Phuan PW, Perkins B, Ullman J, May BC, Cohen FE, Prusiner SB. Ghaemmaghami S, et al. Among authors: cohen fe. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):17971-6. doi: 10.1073/pnas.0708372104. Epub 2007 Nov 7. Proc Natl Acad Sci U S A. 2007. PMID: 17989223 Free PMC article.
Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes.
Legname G, Nguyen HO, Peretz D, Cohen FE, DeArmond SJ, Prusiner SB. Legname G, et al. Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19105-10. doi: 10.1073/pnas.0608970103. Epub 2006 Dec 1. Proc Natl Acad Sci U S A. 2006. PMID: 17142317 Free PMC article.
Site-directed mutagenesis demonstrates the plasticity of the beta helix: implications for the structure of the misfolded prion protein.
Choi JH, May BC, Govaerts C, Cohen FE. Choi JH, et al. Among authors: cohen fe. Structure. 2009 Jul 15;17(7):1014-23. doi: 10.1016/j.str.2009.05.013. Structure. 2009. PMID: 19604481 Free article.
Genes contributing to prion pathogenesis.
Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubinstein E, Boucheix C, Yang X, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Moskovitz J, Epstein CJ, Cruz TD, Kuziel WA, Maeda N, Sap J, Ashe KH, Carlson GA, Tesseur I, Wyss-Coray T, Mucke L, Weisgraber KH, Mahley RW, Cohen FE, Prusiner SB. Tamgüney G, et al. Among authors: cohen fe. J Gen Virol. 2008 Jul;89(Pt 7):1777-1788. doi: 10.1099/vir.0.2008/001255-0. J Gen Virol. 2008. PMID: 18559949 Free PMC article.
Electron crystallography of the scrapie prion protein complexed with heavy metals.
Wille H, Govaerts C, Borovinskiy A, Latawiec D, Downing KH, Cohen FE, Prusiner SB. Wille H, et al. Among authors: cohen fe. Arch Biochem Biophys. 2007 Nov 15;467(2):239-48. doi: 10.1016/j.abb.2007.08.010. Epub 2007 Aug 23. Arch Biochem Biophys. 2007. PMID: 17935686 Free PMC article.
Automatic extraction of protein point mutations using a graph bigram association.
Lee LC, Horn F, Cohen FE. Lee LC, et al. PLoS Comput Biol. 2007 Feb 2;3(2):e16. doi: 10.1371/journal.pcbi.0030016. PLoS Comput Biol. 2007. PMID: 17274683 Free PMC article.
Developing therapeutics for the diseases of protein misfolding.
May BC, Govaerts C, Cohen FE. May BC, et al. Neurology. 2006 Jan 24;66(2 Suppl 1):S118-22. doi: 10.1212/01.wnl.0000192309.26571.a7. Neurology. 2006. PMID: 16432139 Review.
Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues.
Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, Cohen FE, Prusiner SB, Baldwin MA. Schmitt-Ulms G, et al. Nat Biotechnol. 2004 Jun;22(6):724-31. doi: 10.1038/nbt969. Epub 2004 May 16. Nat Biotechnol. 2004. PMID: 15146195
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