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Prosomatostatin processing in Neuro2A cells. Role of beta-turn structure in the vicinity of the Arg-Lys cleavage site.
Brakch N, Boileau G, Simonetti M, Nault C, Joseph-Bravo P, Rholam M, Cohen P. Brakch N, et al. Among authors: cohen p. Eur J Biochem. 1993 Aug 15;216(1):39-47. doi: 10.1111/j.1432-1033.1993.tb18114.x. Eur J Biochem. 1993. PMID: 8103453 Free article.
Proline residues located near the processing sites of human prosomatostatin were previously shown to be important for cleavage of the precursor into somatostatin 28 and somatostatin 14 [Gomez, S., Boileau, G., Zollinger, L., Nault, C., Rholam, M. & Cohen, P. (19 …
Proline residues located near the processing sites of human prosomatostatin were previously shown to be important for cleavage of the precur …
Role of beta-turn in proteolytic processing of peptide hormone precursors at dibasic sites.
Brakch N, Rholam M, Boussetta H, Cohen P. Brakch N, et al. Among authors: cohen p. Biochemistry. 1993 May 11;32(18):4925-30. doi: 10.1021/bi00069a029. Biochemistry. 1993. PMID: 8490028
Proteolytic activation of prohormones and proproteins occurs most frequently at the level of basic amino acids arranged in doublets. Previous predictions by Rholam et al. [Rholam, M., Nicolas, P., & Cohen, P. (1986) FEBS Lett. 207. 1-6] have indicated, on …
Proteolytic activation of prohormones and proproteins occurs most frequently at the level of basic amino acids arranged in doublets. Previou …
Evidence for the presence of a secondary structure at the dibasic processing site of prohormone: the pro-ocytocin model.
Paolillo L, Simonetti M, Brakch N, D'Auria G, Saviano M, Dettin M, Rholam M, Scatturin A, Di Bello C, Cohen P. Paolillo L, et al. Among authors: cohen p. EMBO J. 1992 Jul;11(7):2399-405. doi: 10.1002/j.1460-2075.1992.tb05304.x. EMBO J. 1992. PMID: 1628613 Free PMC article.
Thus it has been proposed, on the basis of secondary structure predictions [Rholam, M., Nicolas, P. and Cohen, P. (1986) FEBS Lett., 207, 1-6], that those basic residues which operate as signal loci for the proteolytic enzyme machinery are situated in, or nex …
Thus it has been proposed, on the basis of secondary structure predictions [Rholam, M., Nicolas, P. and Cohen, P. (1986 …
4,300 results