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Ppm1E is an in cellulo AMP-activated protein kinase phosphatase.
Voss M, Paterson J, Kelsall IR, Martín-Granados C, Hastie CJ, Peggie MW, Cohen PT. Voss M, et al. Cell Signal. 2011 Jan;23(1):114-24. doi: 10.1016/j.cellsig.2010.08.010. Epub 2010 Aug 27. Cell Signal. 2011. PMID: 20801214
Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases.
Martin-Granados C, Philp A, Oxenham SK, Prescott AR, Cohen PT. Martin-Granados C, et al. Int J Biochem Cell Biol. 2008;40(10):2315-32. doi: 10.1016/j.biocel.2008.03.021. Epub 2008 Apr 8. Int J Biochem Cell Biol. 2008. PMID: 18487071
The hepatic PP1 glycogen-targeting subunit interaction with phosphorylase a can be blocked by C-terminal tyrosine deletion or an indole drug.
Kelsall IR, Munro S, Hallyburton I, Treadway JL, Cohen PT. Kelsall IR, et al. FEBS Lett. 2007 Oct 2;581(24):4749-53. doi: 10.1016/j.febslet.2007.08.073. Epub 2007 Sep 6. FEBS Lett. 2007. PMID: 17870073
The Saccharomyces cerevisiae orthologue of the human protein phosphatase 4 core regulatory subunit R2 confers resistance to the anticancer drug cisplatin.
Hastie CJ, Vázquez-Martin C, Philp A, Stark MJ, Cohen PT. Hastie CJ, et al. FEBS J. 2006 Jul;273(14):3322-34. doi: 10.1111/j.1742-4658.2006.05336.x. FEBS J. 2006. PMID: 16857015
A novel glycogen-targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodents.
Munro S, Ceulemans H, Bollen M, Diplexcito J, Cohen PT. Munro S, et al. FEBS J. 2005 Mar;272(6):1478-89. doi: 10.1111/j.1742-4658.2005.04585.x. FEBS J. 2005. PMID: 15752363
Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole.
Zeke T, Morrice N, Vázquez-Martin C, Cohen PT. Zeke T, et al. Biochem J. 2005 Jan 1;385(Pt 1):45-56. doi: 10.1042/BJ20040690. Biochem J. 2005. PMID: 15383005 Free PMC article.
Protein phosphatase 1--targeted in many directions.
Cohen PT. Cohen PT. J Cell Sci. 2002 Jan 15;115(Pt 2):241-56. J Cell Sci. 2002. PMID: 11839776 Review.
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