Colby D - Search Results

1

Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library.

Feldhaus MJ, Siegel RW, Opresko LK, Coleman JR, Feldhaus JM, Yeung YA, Cochran JR, Heinzelman P, Colby D, Swers J, Graff C, Wiley HS, Wittrup KD. Feldhaus MJ, et al. Among authors: colby d. Nat Biotechnol. 2003 Feb;21(2):163-70. doi: 10.1038/nbt785. Epub 2003 Jan 21. Nat Biotechnol. 2003. PMID: 12536217

2

Engineering antibody affinity by yeast surface display.

Colby DW, Kellogg BA, Graff CP, Yeung YA, Swers JS, Wittrup KD. Colby DW, et al. Methods Enzymol. 2004;388:348-58. doi: 10.1016/S0076-6879(04)88027-3. Methods Enzymol. 2004. PMID: 15289082 No abstract available.

3

Development of a human light chain variable domain (V(L)) intracellular antibody specific for the amino terminus of huntingtin via yeast surface display.

Colby DW, Garg P, Holden T, Chao G, Webster JM, Messer A, Ingram VM, Wittrup KD. Colby DW, et al. J Mol Biol. 2004 Sep 17;342(3):901-12. doi: 10.1016/j.jmb.2004.07.054. J Mol Biol. 2004. PMID: 15342245

4

Stochastic kinetics of intracellular huntingtin aggregate formation.

Colby DW, Cassady JP, Lin GC, Ingram VM, Wittrup KD. Colby DW, et al. Nat Chem Biol. 2006 Jun;2(6):319-23. doi: 10.1038/nchembio792. Epub 2006 May 14. Nat Chem Biol. 2006. PMID: 16699519

5

Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody.

Colby DW, Chu Y, Cassady JP, Duennwald M, Zazulak H, Webster JM, Messer A, Lindquist S, Ingram VM, Wittrup KD. Colby DW, et al. Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17616-21. doi: 10.1073/pnas.0408134101. Epub 2004 Dec 14. Proc Natl Acad Sci U S A. 2004. PMID: 15598740 Free PMC article.

6

A disulfide-free single-domain V(L) intrabody with blocking activity towards huntingtin reveals a novel mode of epitope recognition.

Schiefner A, Chatwell L, Körner J, Neumaier I, Colby DW, Volkmer R, Wittrup KD, Skerra A. Schiefner A, et al. J Mol Biol. 2011 Dec 2;414(3):337-55. doi: 10.1016/j.jmb.2011.09.034. Epub 2011 Sep 24. J Mol Biol. 2011. PMID: 21968397

7

Conformation-dependent epitopes recognized by prion protein antibodies probed using mutational scanning and deep sequencing.

Doolan KM, Colby DW. Doolan KM, et al. J Mol Biol. 2015 Jan 30;427(2):328-40. doi: 10.1016/j.jmb.2014.10.024. Epub 2014 Nov 7. J Mol Biol. 2015. PMID: 25451031 Free PMC article.

8

Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease.

Barbaro BA, Lukacsovich T, Agrawal N, Burke J, Bornemann DJ, Purcell JM, Worthge SA, Caricasole A, Weiss A, Song W, Morozova OA, Colby DW, Marsh JL. Barbaro BA, et al. Hum Mol Genet. 2015 Feb 15;24(4):913-25. doi: 10.1093/hmg/ddu504. Epub 2014 Oct 9. Hum Mol Genet. 2015. PMID: 25305076 Free PMC article.

9

De novo generation of prion strains.

Colby DW, Prusiner SB. Colby DW, et al. Nat Rev Microbiol. 2011 Sep 26;9(11):771-7. doi: 10.1038/nrmicro2650. Nat Rev Microbiol. 2011. PMID: 21947062 Free PMC article. Review.

10

Small-molecule aggregates inhibit amyloid polymerization.

Feng BY, Toyama BH, Wille H, Colby DW, Collins SR, May BC, Prusiner SB, Weissman J, Shoichet BK. Feng BY, et al. Nat Chem Biol. 2008 Mar;4(3):197-9. doi: 10.1038/nchembio.65. Epub 2008 Jan 27. Nat Chem Biol. 2008. PMID: 18223646 Free PMC article.

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