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A novel class of ion displacement ligands as antagonists of the αIIbβ3 receptor that limit conformational reorganization of the receptor.
Jiang JK, McCoy JG, Shen M, LeClair CA, Huang W, Negri A, Li J, Blue R, Harrington AW, Naini S, David G 3rd, Choi WS, Volpi E, Fernandez J, Babayeva M, Nedelman MA, Filizola M, Coller BS, Thomas CJ. Jiang JK, et al. Among authors: coller bs. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1148-53. doi: 10.1016/j.bmcl.2013.12.122. Epub 2014 Jan 8. Bioorg Med Chem Lett. 2014. PMID: 24461295 Free PMC article.
Three novel beta-propeller mutations causing Glanzmann thrombasthenia result in production of normally stable pro-alphaIIb, but variably impaired progression of pro-alphaIIbbeta3 from endoplasmic reticulum to Golgi.
Nelson EJ, Li J, Mitchell WB, Chandy M, Srivastava A, Coller BS. Nelson EJ, et al. Among authors: coller bs. J Thromb Haemost. 2005 Dec;3(12):2773-83. doi: 10.1111/j.1538-7836.2005.01593.x. J Thromb Haemost. 2005. PMID: 16359515 Free PMC article.
284 results