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Role of phytochemicals in the management of metabolic syndrome.
Cicero AF, Colletti A. Cicero AF, et al. Phytomedicine. 2016 Oct 15;23(11):1134-44. doi: 10.1016/j.phymed.2015.11.009. Epub 2015 Dec 11. Phytomedicine. 2016. PMID: 26778479 Review.
The basis of this "epidemic" is either a diet too often characterized by excessive consumption of saturated and trans-esterified fatty acids, simple sugars and salt, either a sedentary lifestyle. ...CONCLUSION: Some nutraceuticals, when adequately dosed, should impr …
The basis of this "epidemic" is either a diet too often characterized by excessive consumption of saturated and trans-esterified fatt …
Nutraceuticals and Blood Pressure Control: Results from Clinical Trials and Meta-Analyses.
Cicero AF, Colletti A. Cicero AF, et al. High Blood Press Cardiovasc Prev. 2015 Sep;22(3):203-13. doi: 10.1007/s40292-015-0081-8. Epub 2015 Mar 19. High Blood Press Cardiovasc Prev. 2015. PMID: 25788027 Review.
Beyond the well-known effects on blood pressure (BP) of the dietary approaches to stop hypertension (DASH) and the Mediterranean diets, a large number of studies has investigated the possible BP lowering effect of different dietary supplements and nutraceuticals, the most …
Beyond the well-known effects on blood pressure (BP) of the dietary approaches to stop hypertension (DASH) and the Mediterranean diets, a
Combinations of phytomedicines with different lipid lowering activity for dyslipidemia management: The available clinical data.
Cicero AF, Colletti A. Cicero AF, et al. Phytomedicine. 2016 Oct 15;23(11):1113-8. doi: 10.1016/j.phymed.2015.10.011. Epub 2015 Nov 10. Phytomedicine. 2016. PMID: 26621556 Review.
Dyslipidemia is a major independent and reversible risk factor for these diseases: it is estimated that a reduction of 1 mmol/l (38 mg/dl) of LDL cholesterol is associated with a risk of developing a cardiovascular complication reduced by 25%, a
Dyslipidemia is a major independent and reversible risk factor for these diseases: it is estimated that a reduction of 1 mmol/ …
Effect of Lactotripeptides (Isoleucine-Proline-Proline/Valine-Proline-Proline) on Blood Pressure and Arterial Stiffness Changes in Subjects with Suboptimal Blood Pressure Control and Metabolic Syndrome: A Double-Blind, Randomized, Crossover Clinical Trial.
Cicero AF, Colletti A, Rosticci M, Cagnati M, Urso R, Giovannini M, Borghi C, D'Addato S. Cicero AF, et al. Metab Syndr Relat Disord. 2016 Apr;14(3):161-6. doi: 10.1089/met.2015.0093. Epub 2015 Dec 18. Metab Syndr Relat Disord. 2016. PMID: 26683986 Clinical Trial.
BACKGROUND: Lactotripeptides (LTPs) have a mild antihypertensive effect in hypertensive subjects. The main aim of our clinical trial was to test if LTPs could have some influence on blood pressure (BP) and related hemodynamic parameters in a sample of outpatients af …
BACKGROUND: Lactotripeptides (LTPs) have a mild antihypertensive effect in hypertensive subjects. The main aim of our clinical trial …
Effects of a Combined Nutraceutical on Lipid Pattern, Glucose Metabolism and Inflammatory Parameters in Moderately Hypercholesterolemic Subjects: A Double-blind, Cross-over, Randomized Clinical Trial.
Cicero AF, Colletti A, Fogacci F, Bove M, Rosticci M, Borghi C. Cicero AF, et al. High Blood Press Cardiovasc Prev. 2017 Mar;24(1):13-18. doi: 10.1007/s40292-016-0163-2. Epub 2016 Jun 23. High Blood Press Cardiovasc Prev. 2017. PMID: 27339779 Free PMC article. Clinical Trial.
After a period of 3 weeks of dietary habits correction, patients began a period of 6 weeks of treatment with nutraceutical or placebo, followed by 2 weeks of washout and finally 6 weeks in cross-over. ...Further confirmation are needed to verify these observations o …
After a period of 3 weeks of dietary habits correction, patients began a period of 6 weeks of treatment with nutraceutical or …
Efficacy and tolerability of a combined lipid-lowering nutraceutical on cholesterolemia, hs-CRP level and endothelial function in moderately hypercholesterolemic subjects.
Cicero AF, Colletti A, Rosticci M, Grandi E, Borghi C. Cicero AF, et al. J Biol Regul Homeost Agents. 2016 Apr-Jun;30(2):593-8. J Biol Regul Homeost Agents. 2016. PMID: 27358154 Clinical Trial.
Our aim was to test, by a double-blind, placebo-controlled randomized clinical trial, whether a short-term treatment with a combined lipid-lowering nutraceutical could improve endothelial function in a cohort of moderately hypercholesterolemic subjects …
Our aim was to test, by a double-blind, placebo-controlled randomized clinical trial, whether a short-term treatment with a
Potential role of bioactive peptides in prevention and treatment of chronic diseases: a narrative review.
Cicero AFG, Fogacci F, Colletti A. Cicero AFG, et al. Br J Pharmacol. 2017 Jun;174(11):1378-1394. doi: 10.1111/bph.13608. Epub 2016 Sep 29. Br J Pharmacol. 2017. PMID: 27572703 Free PMC article. Review.
Many bioactive peptides show selective cytotoxic activity against a wide range of cancer cell lines in vitro and in vivo, whereas others have immunomodulatory and antimicrobial effects. ...However, clinical evidence is at an early stage, and there is a need for soli …
Many bioactive peptides show selective cytotoxic activity against a wide range of cancer cell lines in vitro and in vivo, whereas oth …
Nutraceuticals and Dietary Supplements to Improve Quality of Life and Outcomes in Heart Failure Patients.
Cicero AFG, Colletti A. Cicero AFG, et al. Curr Pharm Des. 2017;23(8):1265-1272. doi: 10.2174/1381612823666170124120518. Curr Pharm Des. 2017. PMID: 28120718 Review.
BACKGROUND: Heart failure (HF) is a complex clinical syndrome that can result from any structural or functional cardiac disorder that impairs the ability of the ventricle to fill or eject blood. It represents a major public health issue, with a prevalence of …
BACKGROUND: Heart failure (HF) is a complex clinical syndrome that can result from any structural or functional cardiac disorder that …
Effects of Carotenoids on Health: Are All the Same? Results from Clinical Trials.
Cicero AFG, Colletti A. Cicero AFG, et al. Curr Pharm Des. 2017;23(17):2422-2427. doi: 10.2174/1381612823666170207095459. Curr Pharm Des. 2017. PMID: 28176669 Review.
BACKGROUND: Oxidative stress is implicated in the pathogenesis of a lot of age-related pathologies and some types of cancers. ...Therefore, it is necessary to test them alone and to evaluate their safety in longterm clinical trials on a large and heterogeneous sampl …
BACKGROUND: Oxidative stress is implicated in the pathogenesis of a lot of age-related pathologies and some types of cancers. ...Ther …
Nutraceutical Effects on Glucose and Lipid Metabolism in Patients with Impaired Fasting Glucose: A Pilot, Double-Blind, Placebo-Controlled, Randomized Clinical Trial on a Combined Product.
Cicero AFG, Fogacci F, Morbini M, Colletti A, Bove M, Veronesi M, Giovannini M, Borghi C. Cicero AFG, et al. High Blood Press Cardiovasc Prev. 2017 Sep;24(3):283-288. doi: 10.1007/s40292-017-0206-3. Epub 2017 May 23. High Blood Press Cardiovasc Prev. 2017. PMID: 28537012 Free PMC article. Clinical Trial.
After a period of 2 weeks of dietary habits correction only, patients continued the diet and began a period of 8 weeks of treatment with nutraceutical or placebo. ...Further confirmation is needed to verify these observations on the middle and long term with a
After a period of 2 weeks of dietary habits correction only, patients continued the diet and began a period of 8 weeks of trea …
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