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C-terminal peptides modelling constitutive PrPC processing demonstrate ameliorated toxicity predisposition consequent to α-cleavage.
Johanssen VA, Johanssen T, Masters CL, Hill AF, Barnham KJ, Collins SJ. Johanssen VA, et al. Among authors: collins sj. Biochem J. 2014 Apr 1;459(1):103-15. doi: 10.1042/BJ20131378. Biochem J. 2014. PMID: 24438129
Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation.
White AR, Maher F, Brazier MW, Jobling MF, Thyer J, Stewart LR, Thompson A, Gibson R, Masters CL, Multhaup G, Beyreuther K, Barrow CJ, Collins SJ, Cappai R. White AR, et al. Among authors: collins sj. Brain Res. 2003 Mar 21;966(2):231-44. doi: 10.1016/s0006-8993(02)04173-2. Brain Res. 2003. PMID: 12618346
Prion protein glycosylation.
Lawson VA, Collins SJ, Masters CL, Hill AF. Lawson VA, et al. Among authors: collins sj. J Neurochem. 2005 May;93(4):793-801. doi: 10.1111/j.1471-4159.2005.03104.x. J Neurochem. 2005. PMID: 15857383 Review.
Extended period of asymptomatic prion disease after low dose inoculation: assessment of detection methods and implications for infection control.
Collins SJ, Lewis V, Brazier MW, Hill AF, Lawson VA, Klug GM, Masters CL. Collins SJ, et al. Neurobiol Dis. 2005 Nov;20(2):336-46. doi: 10.1016/j.nbd.2005.03.014. Neurobiol Dis. 2005. PMID: 16242640
A manganese-superoxide dismutase/catalase mimetic extends survival in a mouse model of human prion disease.
Brazier MW, Doctrow SR, Masters CL, Collins SJ. Brazier MW, et al. Among authors: collins sj. Free Radic Biol Med. 2008 Jul 15;45(2):184-92. doi: 10.1016/j.freeradbiomed.2008.04.006. Epub 2008 Apr 16. Free Radic Biol Med. 2008. PMID: 18455516
Analysis of endogenous PrPC processing in neuronal and non-neuronal cell lines.
Lewis V, Collins SJ. Lewis V, et al. Among authors: collins sj. Methods Mol Biol. 2008;459:229-39. doi: 10.1007/978-1-59745-234-2_15. Methods Mol Biol. 2008. PMID: 18576158
Mouse-adapted sporadic human Creutzfeldt-Jakob disease prions propagate in cell culture.
Lawson VA, Vella LJ, Stewart JD, Sharples RA, Klemm H, Machalek DM, Masters CL, Cappai R, Collins SJ, Hill AF. Lawson VA, et al. Among authors: collins sj. Int J Biochem Cell Biol. 2008;40(12):2793-801. doi: 10.1016/j.biocel.2008.05.024. Epub 2008 Jun 11. Int J Biochem Cell Biol. 2008. PMID: 18590830
Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response.
Haigh CL, Drew SC, Boland MP, Masters CL, Barnham KJ, Lawson VA, Collins SJ. Haigh CL, et al. Among authors: collins sj. J Cell Sci. 2009 May 15;122(Pt 10):1518-28. doi: 10.1242/jcs.043604. Epub 2009 Apr 21. J Cell Sci. 2009. PMID: 19383722
PrPC-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site.
Haigh CL, Lewis VA, Vella LJ, Masters CL, Hill AF, Lawson VA, Collins SJ. Haigh CL, et al. Among authors: collins sj. Cell Res. 2009 Sep;19(9):1062-78. doi: 10.1038/cr.2009.86. Epub 2009 Jul 14. Cell Res. 2009. PMID: 19597535
Therapeutic interventions ameliorating prion disease.
Brazier MW, Wall VA, Brazier BW, Masters CL, Collins SJ. Brazier MW, et al. Among authors: collins sj. Expert Rev Anti Infect Ther. 2009 Feb;7(1):83-105. doi: 10.1586/14787210.7.1.83. Expert Rev Anti Infect Ther. 2009. PMID: 19622059 Review.
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