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Rapamycin passes the torch: a new generation of mTOR inhibitors.
Benjamin D, Colombi M, Moroni C, Hall MN. Benjamin D, et al. Among authors: colombi m. Nat Rev Drug Discov. 2011 Oct 31;10(11):868-80. doi: 10.1038/nrd3531. Nat Rev Drug Discov. 2011. PMID: 22037041 Review.
An isogenic cell panel identifies compounds that inhibit proliferation of mTOR-pathway addicted cells by different mechanisms.
Wyder Peters L, Molle KD, Thiemeyer A, Knopf A, Goxe M, Guerry P, Brodbeck D, Colombi M, Hall MN, Moroni C, Regenass U. Wyder Peters L, et al. Among authors: colombi m. J Biomol Screen. 2014 Jan;19(1):131-44. doi: 10.1177/1087057113497798. Epub 2013 Aug 16. J Biomol Screen. 2014. PMID: 23954931
The protein histidine phosphatase LHPP is a tumour suppressor.
Hindupur SK, Colombi M, Fuhs SR, Matter MS, Guri Y, Adam K, Cornu M, Piscuoglio S, Ng CKY, Betz C, Liko D, Quagliata L, Moes S, Jenoe P, Terracciano LM, Heim MH, Hunter T, Hall MN. Hindupur SK, et al. Among authors: colombi m. Nature. 2018 Mar 29;555(7698):678-682. doi: 10.1038/nature26140. Epub 2018 Mar 21. Nature. 2018. PMID: 29562234 Free PMC article.
mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue.
Albert V, Svensson K, Shimobayashi M, Colombi M, Muñoz S, Jimenez V, Handschin C, Bosch F, Hall MN. Albert V, et al. Among authors: colombi m. EMBO Mol Med. 2016 Mar 1;8(3):232-46. doi: 10.15252/emmm.201505610. EMBO Mol Med. 2016. PMID: 26772600 Free PMC article.
mTORC2 Promotes Tumorigenesis via Lipid Synthesis.
Guri Y, Colombi M, Dazert E, Hindupur SK, Roszik J, Moes S, Jenoe P, Heim MH, Riezman I, Riezman H, Hall MN. Guri Y, et al. Among authors: colombi m. Cancer Cell. 2017 Dec 11;32(6):807-823.e12. doi: 10.1016/j.ccell.2017.11.011. Cancer Cell. 2017. PMID: 29232555
Syrosingopine sensitizes cancer cells to killing by metformin.
Benjamin D, Colombi M, Hindupur SK, Betz C, Lane HA, El-Shemerly MY, Lu M, Quagliata L, Terracciano L, Moes S, Sharpe T, Wodnar-Filipowicz A, Moroni C, Hall MN. Benjamin D, et al. Among authors: colombi m. Sci Adv. 2016 Dec 23;2(12):e1601756. doi: 10.1126/sciadv.1601756. eCollection 2016 Dec. Sci Adv. 2016. PMID: 28028542 Free PMC article.
Genome-wide shRNA screen reveals increased mitochondrial dependence upon mTORC2 addiction.
Colombi M, Molle KD, Benjamin D, Rattenbacher-Kiser K, Schaefer C, Betz C, Thiemeyer A, Regenass U, Hall MN, Moroni C. Colombi M, et al. Oncogene. 2011 Mar 31;30(13):1551-65. doi: 10.1038/onc.2010.539. Epub 2010 Dec 20. Oncogene. 2011. PMID: 21170086
Quantitative proteomics and phosphoproteomics on serial tumor biopsies from a sorafenib-treated HCC patient.
Dazert E, Colombi M, Boldanova T, Moes S, Adametz D, Quagliata L, Roth V, Terracciano L, Heim MH, Jenoe P, Hall MN. Dazert E, et al. Among authors: colombi m. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1381-6. doi: 10.1073/pnas.1523434113. Epub 2016 Jan 19. Proc Natl Acad Sci U S A. 2016. PMID: 26787912 Free PMC article.
Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover.
Stoecklin G, Colombi M, Raineri I, Leuenberger S, Mallaun M, Schmidlin M, Gross B, Lu M, Kitamura T, Moroni C. Stoecklin G, et al. Among authors: colombi m. EMBO J. 2002 Sep 2;21(17):4709-18. doi: 10.1093/emboj/cdf444. EMBO J. 2002. PMID: 12198173 Free PMC article.
Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells.
Benjamin D, Robay D, Hindupur SK, Pohlmann J, Colombi M, El-Shemerly MY, Maira SM, Moroni C, Lane HA, Hall MN. Benjamin D, et al. Among authors: colombi m. Cell Rep. 2018 Dec 11;25(11):3047-3058.e4. doi: 10.1016/j.celrep.2018.11.043. Cell Rep. 2018. PMID: 30540938 Free PMC article.
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