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Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice.
Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA, Miyamoto Y, Eckmann L, Dhungana S, Pathmasiri W, Sumner S, Westwater C, Brenner DA, Schnabl B. Mazagova M, et al. FASEB J. 2015 Mar;29(3):1043-55. doi: 10.1096/fj.14-259515. Epub 2014 Dec 2. FASEB J. 2015. PMID: 25466902 Free PMC article.
Increased liver fibrosis was observed in GF mice compared with conventional mice. Hepatocytes showed more toxin-induced oxidative stress and cell death. ...Isolated Myd88/Trif-deficient hepatocytes were more susceptible to toxin-induced cell death in c …
Increased liver fibrosis was observed in GF mice compared with conventional mice. Hepatocytes showed more toxin- …
Peptidoglycan isolated from the fruit of Lycium barbarum alleviates liver fibrosis in mice by regulating the TGF-beta/Smad7 signaling and gut microbiota.
Nie YM, Zhou WQ, Niu T, Mao MF, Zhan YX, Li Y, Wang KP, Li MX, Ding K. Nie YM, et al. Acta Pharmacol Sin. 2025 Jan 20. doi: 10.1038/s41401-024-01454-x. Online ahead of print. Acta Pharmacol Sin. 2025. PMID: 39833303
In this study, we investigated the hepatoprotective mechanisms of LBPW. CCl(4)-induced liver fibrosis mice were administered LBPW (50, 100, 200 mg .kg(-1) .d(-1), i.p.) or (100, 200, 300 mg. kg(-1) .d(-1), i.g.) for 6 weeks. ...In TGF-beta1-stimulated …
In this study, we investigated the hepatoprotective mechanisms of LBPW. CCl(4)-induced liver fibrosis mice were …