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Comparative characterisation of two nitroreductases from Giardia lamblia as potential activators of nitro compounds.
Müller J, Rout S, Leitsch D, Vaithilingam J, Hehl A, Müller N. Müller J, et al. Int J Parasitol Drugs Drug Resist. 2015 Mar 25;5(2):37-43. doi: 10.1016/j.ijpddr.2015.03.001. eCollection 2015 Aug. Int J Parasitol Drugs Drug Resist. 2015. PMID: 27099829 Free PMC article.
Giardia lamblia is a protozoan parasite that causes giardiasis, a diarrhoeal disease affecting humans and various animal species. ...Nitroreductases such as GlNR1 and GlNR2 may play a role in activation or inactivation of these drugs. The aim of this w
Giardia lamblia is a protozoan parasite that causes giardiasis, a diarrhoeal disease affecting humans and various animal speci
Characterization of Giardia lamblia WB C6 clones resistant to nitazoxanide and to metronidazole.
Müller J, Sterk M, Hemphill A, Müller N. Müller J, et al. J Antimicrob Chemother. 2007 Aug;60(2):280-7. doi: 10.1093/jac/dkm205. Epub 2007 Jun 8. J Antimicrob Chemother. 2007. PMID: 17561498 Free article.
OBJECTIVES: The characterization of Giardia lamblia WB C6 strains resistant to metronidazole and to the nitro-thiazole nitazoxanide [2-acetolyloxy-N-(5-nitro 2-thiazolyl) benzamide] as the parent compound of thiazolides, a novel class of anti-infective drugs …
OBJECTIVES: The characterization of Giardia lamblia WB C6 strains resistant to metronidazole and to the nitro-thiazole …
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