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Complex host genetic susceptibility to Staphylococcus aureus infections.
Shukla SK, Rose W, Schrodi SJ. Shukla SK, et al. Trends Microbiol. 2015 Sep;23(9):529-36. doi: 10.1016/j.tim.2015.05.008. Epub 2015 Jun 22. Trends Microbiol. 2015. PMID: 26112911 Review.
Understanding of the host genetic susceptibility to carriage of, and infections, due to Staphylococcus aureus, a nosocomial pathogen, is still in its nascent stages. Mouse models show variable susceptibility to S. aureus
Understanding of the host genetic susceptibility to carriage of, and infections, due to Staphylococcus
The evolution of vancomycin intermediate Staphylococcus aureus (VISA) and heterogenous-VISA.
Howden BP, Peleg AY, Stinear TP. Howden BP, et al. Infect Genet Evol. 2014 Jan;21:575-82. doi: 10.1016/j.meegid.2013.03.047. Epub 2013 Apr 6. Infect Genet Evol. 2014. PMID: 23567819 Review.
Resistance to new antimicrobials is generally recognized in Staphylococcus aureus soon after they are released for clinical use. ...Unraveling the complex genetic and cell wall structural changes conferring low-level vancomycin resistance in S. …
Resistance to new antimicrobials is generally recognized in Staphylococcus aureus soon after they are released for clinical us …
Wall teichoic acids of Staphylococcus aureus limit recognition by the drosophila peptidoglycan recognition protein-SA to promote pathogenicity.
Atilano ML, Yates J, Glittenberg M, Filipe SR, Ligoxygakis P. Atilano ML, et al. PLoS Pathog. 2011 Dec;7(12):e1002421. doi: 10.1371/journal.ppat.1002421. Epub 2011 Dec 1. PLoS Pathog. 2011. PMID: 22144903 Free PMC article.
The absence of WTA has been associated with a reduced pathogenicity of Staphylococcus aureus (S. aureus). Here, we assessed whether this was due to increased detection of PG, an important target of innate immune receptors. Antibiotic-mediated or gen
The absence of WTA has been associated with a reduced pathogenicity of Staphylococcus aureus (S. aureus). Here, …
A genome-wide association study of variants associated with acquisition of Staphylococcus aureus bacteremia in a healthcare setting.
Nelson CL, Pelak K, Podgoreanu MV, Ahn SH, Scott WK, Allen AS, Cowell LG, Rude TH, Zhang Y, Tong A, Ruffin F, Sharma-Kuinkel BK, Fowler VG Jr. Nelson CL, et al. BMC Infect Dis. 2014 Feb 13;14:83. doi: 10.1186/1471-2334-14-83. BMC Infect Dis. 2014. PMID: 24524581 Free PMC article.
BACKGROUND: Humans vary in their susceptibility to acquiring Staphylococcus aureus infection, and research suggests that there is a genetic basis for this variability. ...METHODS: We conducted a GWAS to identify common variants associated with acquisit …
BACKGROUND: Humans vary in their susceptibility to acquiring Staphylococcus aureus infection, and research suggests tha …
Genetic pathway in acquisition and loss of vancomycin resistance in a methicillin resistant Staphylococcus aureus (MRSA) strain of clonal type USA300.
Gardete S, Kim C, Hartmann BM, Mwangi M, Roux CM, Dunman PM, Chambers HF, Tomasz A. Gardete S, et al. PLoS Pathog. 2012 Feb;8(2):e1002505. doi: 10.1371/journal.ppat.1002505. Epub 2012 Feb 2. PLoS Pathog. 2012. PMID: 22319446 Free PMC article.
An isolate of the methicillin-resistant Staphylococcus aureus (MRSA) clone USA300 with reduced susceptibility to vancomycin (SG-R) (i.e, vancomycin-intermediate S. aureus, VISA) and its susceptible "parental" strain (SG-S) were recovered …
An isolate of the methicillin-resistant Staphylococcus aureus (MRSA) clone USA300 with reduced susceptibility to vancom …
Pathogenesis of urinary tract infection. Role of host defenses.
Sobel JD. Sobel JD. Infect Dis Clin North Am. 1997 Sep;11(3):531-49. doi: 10.1016/s0891-5520(05)70372-x. Infect Dis Clin North Am. 1997. PMID: 9378922 Review.
In the last decade, there have been modest strides made in our understanding of the pathogenesis of urinary tract infections (UTIs). Matching the advances achieved in unraveling the complexities of bacterial virulence factors using molecular-genetic technique …
In the last decade, there have been modest strides made in our understanding of the pathogenesis of urinary tract infections (UTIs). …
Within-host diversity of MRSA antimicrobial resistances.
Stanczak-Mrozek KI, Manne A, Knight GM, Gould K, Witney AA, Lindsay JA. Stanczak-Mrozek KI, et al. J Antimicrob Chemother. 2015 Aug;70(8):2191-8. doi: 10.1093/jac/dkv119. Epub 2015 May 8. J Antimicrob Chemother. 2015. PMID: 25957384 Free PMC article.
METHODS: Nasal swabs from 38 MRSA carriers admitted to hospital were plated and 20 individual colonies from each patient tested for phenotypic antibiotic susceptibility and genetically for lineage, carriage of four prophages and three plasmid families. ...Sixty-four differ …
METHODS: Nasal swabs from 38 MRSA carriers admitted to hospital were plated and 20 individual colonies from each patient tested for phenotyp …
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