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Complex host genetic susceptibility to Staphylococcus aureus infections.
Shukla SK, Rose W, Schrodi SJ. Shukla SK, et al. Trends Microbiol. 2015 Sep;23(9):529-36. doi: 10.1016/j.tim.2015.05.008. Epub 2015 Jun 22. Trends Microbiol. 2015. PMID: 26112911 Review.
Understanding of the host genetic susceptibility to carriage of, and infections, due to Staphylococcus aureus, a nosocomial pathogen, is still in its nascent stages. Mouse models show variable susceptibility to S. aureus
Understanding of the host genetic susceptibility to carriage of, and infections, due to Staphylococcus
Genes Influencing Phage Host Range in Staphylococcus aureus on a Species-Wide Scale.
Moller AG, Winston K, Ji S, Wang J, Hargita Davis MN, Solís-Lemus CR, Read TD. Moller AG, et al. mSphere. 2021 Jan 13;6(1):e01263-20. doi: 10.1128/mSphere.01263-20. mSphere. 2021. PMID: 33441407 Free PMC article.
This work illustrates the complexity of the genetic basis for phage susceptibility in S. aureus but also shows that with more data, we may be able to understand much of the variation. With a knowledge of host range determination, we can r …
This work illustrates the complexity of the genetic basis for phage susceptibility in S. aureus but also …
Genetic variation of staphylococcal LukAB toxin determines receptor tropism.
Perelman SS, James DBA, Boguslawski KM, Nelson CW, Ilmain JK, Zwack EE, Prescott RA, Mohamed A, Tam K, Chan R, Narechania A, Pawline MB, Vozhilla N, Moustafa AM, Kim SY, Dittmann M, Ekiert DC, Bhabha G, Shopsin B, Planet PJ, Koralov SB, Torres VJ. Perelman SS, et al. Nat Microbiol. 2021 Jun;6(6):731-745. doi: 10.1038/s41564-021-00890-3. Epub 2021 Apr 19. Nat Microbiol. 2021. PMID: 33875847 Free PMC article.
Staphylococcus aureus has evolved into diverse lineages, known as clonal complexes (CCs), which exhibit differences in the coding sequences of core virulence factors. ...Together, this work advances our understanding of an important S. aureus to
Staphylococcus aureus has evolved into diverse lineages, known as clonal complexes (CCs), which exhibit differences in
The evolution of vancomycin intermediate Staphylococcus aureus (VISA) and heterogenous-VISA.
Howden BP, Peleg AY, Stinear TP. Howden BP, et al. Infect Genet Evol. 2014 Jan;21:575-82. doi: 10.1016/j.meegid.2013.03.047. Epub 2013 Apr 6. Infect Genet Evol. 2014. PMID: 23567819 Review.
Resistance to new antimicrobials is generally recognized in Staphylococcus aureus soon after they are released for clinical use. In the case of vancomycin, which was first released in the 1950s, resistance was not reported until the mid 1990s, with the description o …
Resistance to new antimicrobials is generally recognized in Staphylococcus aureus soon after they are released for clinical us …
Genetic Relatedness and Diversity of Staphylococcus aureus from Different Reservoirs: Humans and Animals of Livestock, Poultry, Zoo, and Aquaculture.
Salgueiro V, Manageiro V, Bandarra NM, Ferreira E, Clemente L, Caniça M. Salgueiro V, et al. Microorganisms. 2020 Sep 3;8(9):1345. doi: 10.3390/microorganisms8091345. Microorganisms. 2020. PMID: 32899267 Free PMC article.
The main aim of this study was the characterization of antibiotic resistance mechanisms in 82 Staphylococcus aureus strains isolated from humans and animals. Antibiotic susceptibility testing was performed on all S. aureus isolates accordingly, …
The main aim of this study was the characterization of antibiotic resistance mechanisms in 82 Staphylococcus aureus strains is …
Wall teichoic acids of Staphylococcus aureus limit recognition by the drosophila peptidoglycan recognition protein-SA to promote pathogenicity.
Atilano ML, Yates J, Glittenberg M, Filipe SR, Ligoxygakis P. Atilano ML, et al. PLoS Pathog. 2011 Dec;7(12):e1002421. doi: 10.1371/journal.ppat.1002421. Epub 2011 Dec 1. PLoS Pathog. 2011. PMID: 22144903 Free PMC article.
The absence of WTA has been associated with a reduced pathogenicity of Staphylococcus aureus (S. aureus). Here, we assessed whether this was due to increased detection of PG, an important target of innate immune receptors. Antibiotic-mediated or gen
The absence of WTA has been associated with a reduced pathogenicity of Staphylococcus aureus (S. aureus). Here, …
Pathogenesis of urinary tract infection. Role of host defenses.
Sobel JD. Sobel JD. Infect Dis Clin North Am. 1997 Sep;11(3):531-49. doi: 10.1016/s0891-5520(05)70372-x. Infect Dis Clin North Am. 1997. PMID: 9378922 Review.
In the last decade, there have been modest strides made in our understanding of the pathogenesis of urinary tract infections (UTIs). Matching the advances achieved in unraveling the complexities of bacterial virulence factors using molecular-genetic technique …
In the last decade, there have been modest strides made in our understanding of the pathogenesis of urinary tract infections (UTIs). …
Genetic pathway in acquisition and loss of vancomycin resistance in a methicillin resistant Staphylococcus aureus (MRSA) strain of clonal type USA300.
Gardete S, Kim C, Hartmann BM, Mwangi M, Roux CM, Dunman PM, Chambers HF, Tomasz A. Gardete S, et al. PLoS Pathog. 2012 Feb;8(2):e1002505. doi: 10.1371/journal.ppat.1002505. Epub 2012 Feb 2. PLoS Pathog. 2012. PMID: 22319446 Free PMC article.
An isolate of the methicillin-resistant Staphylococcus aureus (MRSA) clone USA300 with reduced susceptibility to vancomycin (SG-R) (i.e, vancomycin-intermediate S. aureus, VISA) and its susceptible "parental" strain (SG-S) were recovered …
An isolate of the methicillin-resistant Staphylococcus aureus (MRSA) clone USA300 with reduced susceptibility to vancom …
Within-host diversity of MRSA antimicrobial resistances.
Stanczak-Mrozek KI, Manne A, Knight GM, Gould K, Witney AA, Lindsay JA. Stanczak-Mrozek KI, et al. J Antimicrob Chemother. 2015 Aug;70(8):2191-8. doi: 10.1093/jac/dkv119. Epub 2015 May 8. J Antimicrob Chemother. 2015. PMID: 25957384 Free PMC article.
METHODS: Nasal swabs from 38 MRSA carriers admitted to hospital were plated and 20 individual colonies from each patient tested for phenotypic antibiotic susceptibility and genetically for lineage, carriage of four prophages and three plasmid families. ...If a single colon …
METHODS: Nasal swabs from 38 MRSA carriers admitted to hospital were plated and 20 individual colonies from each patient tested for phenotyp …
Host-Microbe Interaction on the Skin and Its Role in the Pathogenesis and Treatment of Atopic Dermatitis.
Nowicka D, Chilicka K, Dzieńdziora-Urbińska I. Nowicka D, et al. Pathogens. 2022 Jan 6;11(1):71. doi: 10.3390/pathogens11010071. Pathogens. 2022. PMID: 35056019 Free PMC article. Review.
Atopic dermatitis (AD) is a condition with a complex and unclear aetiology. Possible causes of AD encompass alterations in the structure and function of the epidermal barrier, disturbances in the skin microbiome, immune factors, allergens, bacterial and fungal infection
Atopic dermatitis (AD) is a condition with a complex and unclear aetiology. Possible causes of AD encompass alterations in the struct …
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