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Complex host genetic susceptibility to Staphylococcus aureus infections.
Shukla SK, Rose W, Schrodi SJ. Shukla SK, et al. Trends Microbiol. 2015 Sep;23(9):529-36. doi: 10.1016/j.tim.2015.05.008. Epub 2015 Jun 22. Trends Microbiol. 2015. PMID: 26112911 Review.
Understanding of the host genetic susceptibility to carriage of, and infections, due to Staphylococcus aureus, a nosocomial pathogen, is still in its nascent stages. Mouse models show variable susceptibility to S. aureus
Understanding of the host genetic susceptibility to carriage of, and infections, due to Staphylococcus
Comparative genomic analysis of ovine and other host associated isolates of Staphylococcus aureus exhibit the important role of mobile genetic elements and virulence factors in host adaptation.
Lima A, Carolina Barbosa Caetano A, Hurtado Castillo R, Gonçalves Dos Santos R, Lucas Neres Rodrigues D, de Jesus Sousa T, Kato RB, Vinicius Canário Viana M, Cybelle Pinto Gomide A, Figueira Aburjaile F, Tiwari S, Jaiswal A, Gala-García A, Seyffert N, Luiz de Paula Castro T, Brenig B, Matiuzzi da Costa M, Maria Seles Dorneles E, Le Loir Y, Azevedo V. Lima A, et al. Gene. 2023 Mar 1;855:147131. doi: 10.1016/j.gene.2022.147131. Epub 2022 Dec 17. Gene. 2023. PMID: 36539044
Staphylococcus aureus is the main etiological agent of mastitis in small ruminants worldwide. ...This study contributes to the knowledge of genomic specialization and the role of specific genes in establishing infection in ovine mastitis-associated S. aureus.
Staphylococcus aureus is the main etiological agent of mastitis in small ruminants worldwide. ...This study contributes to the
Genes Influencing Phage Host Range in Staphylococcus aureus on a Species-Wide Scale.
Moller AG, Winston K, Ji S, Wang J, Hargita Davis MN, Solís-Lemus CR, Read TD. Moller AG, et al. mSphere. 2021 Jan 13;6(1):e01263-20. doi: 10.1128/mSphere.01263-20. mSphere. 2021. PMID: 33441407 Free PMC article.
Staphylococcus aureus is a human pathogen that causes serious diseases, ranging from skin infections to septic shock. ...This work illustrates the complexity of the genetic basis for phage susceptibility in S. aureus but also shows
Staphylococcus aureus is a human pathogen that causes serious diseases, ranging from skin infections to septic shock. .
Genomic Diversity of Methicillin-Resistant Staphylococcus aureus CC398 Isolates Collected from Diseased Swine in the German National Resistance Monitoring Program GERM-Vet from 2007 to 2019.
Krüger-Haker H, Ji X, Hanke D, Fiedler S, Feßler AT, Jiang N, Kaspar H, Wang Y, Wu C, Schwarz S. Krüger-Haker H, et al. Microbiol Spectr. 2023 Jun 15;11(3):e0077023. doi: 10.1128/spectrum.00770-23. Epub 2023 May 8. Microbiol Spectr. 2023. PMID: 37154741 Free PMC article.
Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) clonal complex 398 (CC398) isolates (n = 178) collected in the national resistance monitoring program GERM-Vet from diseased swine in Germany from 2007 to 2019 were investigated for th …
Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) clonal complex 398 (CC398) isolates (n = 178 …
The evolution of vancomycin intermediate Staphylococcus aureus (VISA) and heterogenous-VISA.
Howden BP, Peleg AY, Stinear TP. Howden BP, et al. Infect Genet Evol. 2014 Jan;21:575-82. doi: 10.1016/j.meegid.2013.03.047. Epub 2013 Apr 6. Infect Genet Evol. 2014. PMID: 23567819 Review.
Unraveling the complex genetic and cell wall structural changes conferring low-level vancomycin resistance in S. aureus has proved challenging. ...These include predicted alterations in central metabolism, altered expression of virulence associated factors, a …
Unraveling the complex genetic and cell wall structural changes conferring low-level vancomycin resistance in S. aureus
Host-Microbe Interaction on the Skin and Its Role in the Pathogenesis and Treatment of Atopic Dermatitis.
Nowicka D, Chilicka K, Dzieńdziora-Urbińska I. Nowicka D, et al. Pathogens. 2022 Jan 6;11(1):71. doi: 10.3390/pathogens11010071. Pathogens. 2022. PMID: 35056019 Free PMC article. Review.
Atopic dermatitis (AD) is a condition with a complex and unclear aetiology. Possible causes of AD encompass alterations in the structure and function of the epidermal barrier, disturbances in the skin microbiome, immune factors, allergens, bacterial and fungal infection
Atopic dermatitis (AD) is a condition with a complex and unclear aetiology. Possible causes of AD encompass alterations in the struct …
Genetic Relatedness and Diversity of Staphylococcus aureus from Different Reservoirs: Humans and Animals of Livestock, Poultry, Zoo, and Aquaculture.
Salgueiro V, Manageiro V, Bandarra NM, Ferreira E, Clemente L, Caniça M. Salgueiro V, et al. Microorganisms. 2020 Sep 3;8(9):1345. doi: 10.3390/microorganisms8091345. Microorganisms. 2020. PMID: 32899267 Free PMC article.
The main aim of this study was the characterization of antibiotic resistance mechanisms in 82 Staphylococcus aureus strains isolated from humans and animals. Antibiotic susceptibility testing was performed on all S. aureus isolates accordingly, and ant …
The main aim of this study was the characterization of antibiotic resistance mechanisms in 82 Staphylococcus aureus strains is …
Genetic variation of staphylococcal LukAB toxin determines receptor tropism.
Perelman SS, James DBA, Boguslawski KM, Nelson CW, Ilmain JK, Zwack EE, Prescott RA, Mohamed A, Tam K, Chan R, Narechania A, Pawline MB, Vozhilla N, Moustafa AM, Kim SY, Dittmann M, Ekiert DC, Bhabha G, Shopsin B, Planet PJ, Koralov SB, Torres VJ. Perelman SS, et al. Nat Microbiol. 2021 Jun;6(6):731-745. doi: 10.1038/s41564-021-00890-3. Epub 2021 Apr 19. Nat Microbiol. 2021. PMID: 33875847 Free PMC article.
Staphylococcus aureus has evolved into diverse lineages, known as clonal complexes (CCs), which exhibit differences in the coding sequences of core virulence factors. ...Together, this work advances our understanding of an important S. aureus toxin and
Staphylococcus aureus has evolved into diverse lineages, known as clonal complexes (CCs), which exhibit differences in
Adaptive laboratory evolution and independent component analysis disentangle complex vancomycin adaptation trajectories.
Fait A, Seif Y, Mikkelsen K, Poudel S, Wells JM, Palsson BO, Ingmer H. Fait A, et al. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2118262119. doi: 10.1073/pnas.2118262119. Epub 2022 Jul 19. Proc Natl Acad Sci U S A. 2022. PMID: 35858453 Free PMC article.
Human infections with methicillin-resistant Staphylococcus aureus (MRSA) are commonly treated with vancomycin, and strains with decreased susceptibility, designated as vancomycin-intermediate S. aureus (VISA), are associated with treatment failu …
Human infections with methicillin-resistant Staphylococcus aureus (MRSA) are commonly treated with vancomycin, and stra …
Wall teichoic acids of Staphylococcus aureus limit recognition by the drosophila peptidoglycan recognition protein-SA to promote pathogenicity.
Atilano ML, Yates J, Glittenberg M, Filipe SR, Ligoxygakis P. Atilano ML, et al. PLoS Pathog. 2011 Dec;7(12):e1002421. doi: 10.1371/journal.ppat.1002421. Epub 2011 Dec 1. PLoS Pathog. 2011. PMID: 22144903 Free PMC article.
The absence of WTA has been associated with a reduced pathogenicity of Staphylococcus aureus (S. aureus). Here, we assessed whether this was due to increased detection of PG, an important target of innate immune receptors. Antibiotic-mediated or genetic
The absence of WTA has been associated with a reduced pathogenicity of Staphylococcus aureus (S. aureus). Here, we asse …
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