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Concepts for agonistic targeting of CD40 in immuno-oncology.
Richards DM, Sefrin JP, Gieffers C, Hill O, Merz C. Richards DM, et al. Hum Vaccin Immunother. 2020;16(2):377-387. doi: 10.1080/21645515.2019.1653744. Epub 2019 Sep 5. Hum Vaccin Immunother. 2020. PMID: 31403344 Free PMC article. Review.
Critically, receptor assembly into functional trimeric signaling complexes occurs through binding of the natural ligand unit. TNF-R-SF members, including CD40, have been key immunotherapeutic targets for over 20 years. CD40, expressed by antigen-presenting ce …
Critically, receptor assembly into functional trimeric signaling complexes occurs through binding of the natural ligand unit. TNF-R-SF membe …
A PDGFRB- and CD40-targeting bispecific AffiMab induces stroma-targeted immune cell activation.
Mega A, Mebrahtu A, Aniander G, Ryer E, Sköld A, Sandegren A, Backström Rydin E, Rockberg J, Östman A, Frejd FY. Mega A, et al. MAbs. 2023 Jan-Dec;15(1):2223750. doi: 10.1080/19420862.2023.2223750. MAbs. 2023. PMID: 37332119 Free PMC article.
A novel PDGFRBxCD40 Fc-silenced bispecific AffiMab was developed to this end to test whether it is possible to activate CD40 in a PDGFRB-targeted manner. A PDGFRB-binding Affibody molecule was fused to each heavy chain of an Fc-silenced CD40 agonistic …
A novel PDGFRBxCD40 Fc-silenced bispecific AffiMab was developed to this end to test whether it is possible to activate CD40 in a PDG …