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Concordance with BRCA1/2 testing guidelines among women in The Health of Women (HOW) Study®.
Silver MI, Klein W, Samimi G, Minasian L, Loud J, Roberts MC. Silver MI, et al. Breast Cancer Res Treat. 2019 Feb;173(3):719-726. doi: 10.1007/s10549-018-5035-0. Epub 2018 Nov 9. Breast Cancer Res Treat. 2019. PMID: 30413980
METHODS: Data included 20,758 women from Dr. Susan Love Research Foundation's The Health of Women (HOW) Study(). ...RESULTS: 3894 women (18.8%) reported BRCA1/2 testing. 5628 (27.1%) women who met NCCN criteria …
METHODS: Data included 20,758 women from Dr. Susan Love Research Foundation's The Health of Women (HOW) Study
Association of Germline Genetic Testing Results With Locoregional and Systemic Therapy in Patients With Breast Cancer.
Kurian AW, Ward KC, Abrahamse P, Hamilton AS, Deapen D, Morrow M, Jagsi R, Katz SJ. Kurian AW, et al. JAMA Oncol. 2020 Apr 1;6(4):e196400. doi: 10.1001/jamaoncol.2019.6400. Epub 2020 Apr 9. JAMA Oncol. 2020. PMID: 32027353 Free PMC article.
Compared with women whose test results were negative, those with BRCA1/2 pathogenic variants were more likely to receive bilateral mastectomy for a unilateral tumor (61.7% vs 24.3%; OR, 5.52, 95% CI, 4.73-6.44), less likely to receive postlumpectomy ra …
Compared with women whose test results were negative, those with BRCA1/2 pathogenic variants were more likely to …
Performance of Breast Cancer Polygenic Risk Scores in 760 Female CHEK2 Germline Mutation Carriers.
Borde J, Ernst C, Wappenschmidt B, Niederacher D, Weber-Lassalle K, Schmidt G, Hauke J, Quante AS, Weber-Lassalle N, Horváth J, Pohl-Rescigno E, Arnold N, Rump A, Gehrig A, Hentschel J, Faust U, Dutrannoy V, Meindl A, Kuzyakova M, Wang-Gohrke S, Weber BHF, Sutter C, Volk AE, Giannakopoulou O, Lee A, Engel C, Schmidt MK, Antoniou AC, Schmutzler RK, Kuchenbaecker K, Hahnen E. Borde J, et al. J Natl Cancer Inst. 2021 Jul 1;113(7):893-899. doi: 10.1093/jnci/djaa203. J Natl Cancer Inst. 2021. PMID: 33372680 Free PMC article.
For PRS calculations, 2 SNP sets covering 77 (SNP set 1, developed for BC risk stratification in women unselected for their BRCA1/2 germline mutation status) and 88 (SNP set 2, developed for BC risk stratification in female BRCA1/2
For PRS calculations, 2 SNP sets covering 77 (SNP set 1, developed for BC risk stratification in women unselected for their …