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Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone.
Tu X, Delgado-Calle J, Condon KW, Maycas M, Zhang H, Carlesso N, Taketo MM, Burr DB, Plotkin LI, Bellido T. Tu X, et al. Among authors: condon kw. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E478-86. doi: 10.1073/pnas.1409857112. Epub 2015 Jan 20. Proc Natl Acad Sci U S A. 2015. PMID: 25605937 Free PMC article.
Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin.
Robling AG, Niziolek PJ, Baldridge LA, Condon KW, Allen MR, Alam I, Mantila SM, Gluhak-Heinrich J, Bellido TM, Harris SE, Turner CH. Robling AG, et al. Among authors: condon kw. J Biol Chem. 2008 Feb 29;283(9):5866-75. doi: 10.1074/jbc.M705092200. Epub 2007 Dec 17. J Biol Chem. 2008. PMID: 18089564 Free article.
Inhibition of osteocyte apoptosis prevents the increase in osteocytic receptor activator of nuclear factor κB ligand (RANKL) but does not stop bone resorption or the loss of bone induced by unloading.
Plotkin LI, Gortazar AR, Davis HM, Condon KW, Gabilondo H, Maycas M, Allen MR, Bellido T. Plotkin LI, et al. Among authors: condon kw. J Biol Chem. 2015 Jul 31;290(31):18934-42. doi: 10.1074/jbc.M115.642090. Epub 2015 Jun 17. J Biol Chem. 2015. PMID: 26085098 Free PMC article.
32 results