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Confirmation of the role of ATG16L1 as a Crohn's disease susceptibility gene.
Cummings JR, Cooney R, Pathan S, Anderson CA, Barrett JC, Beckly J, Geremia A, Hancock L, Guo C, Ahmad T, Cardon LR, Jewell DP. Cummings JR, et al. Inflamm Bowel Dis. 2007 Aug;13(8):941-6. doi: 10.1002/ibd.20162. Inflamm Bowel Dis. 2007. PMID: 17455206
BACKGROUND: A German genome-wide nonsynonymous single nucleotide polymorphism (nsSNP) association study identified ATG16L1 as a Crohn's disease (CD) susceptibility gene. The association appeared to be confined to the nsSNP rs2,241,880 and …
BACKGROUND: A German genome-wide nonsynonymous single nucleotide polymorphism (nsSNP) association study identified ATG16L1 as a Cr
Is there a role for Crohn's disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas?
Wolfkamp SC, Te Velde AA, Weersma RK, Ponsioen CY, Stokkers PC. Wolfkamp SC, et al. Eur J Gastroenterol Hepatol. 2010 Aug;22(8):933-7. doi: 10.1097/MEG.0b013e32833775e6. Eur J Gastroenterol Hepatol. 2010. PMID: 20395867
OBJECTIVE: Autophagy-related 16-like 1 gene (ATG16L1) and immunity-related guanosine triphosphatase gene (IRGM) are associated with Crohn's disease susceptibility and autophagy. ...RESULTS: We confirm the association of the …
OBJECTIVE: Autophagy-related 16-like 1 gene (ATG16L1) and immunity-related guanosine triphosphatase gene (IRGM) are ass …
Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease.
Henckaerts L, Cleynen I, Brinar M, John JM, Van Steen K, Rutgeerts P, Vermeire S. Henckaerts L, et al. Inflamm Bowel Dis. 2011 Jun;17(6):1392-7. doi: 10.1002/ibd.21486. Epub 2010 Nov 28. Inflamm Bowel Dis. 2011. PMID: 21560199
BACKGROUND: The autophagy pathway has been linked with Crohn's disease (CD) through association of the ATG16L1 and IRGM genes with susceptibility for CD, and also to the Nod2 pathway, involved in CD. Our aim was to investigate polymorphis …
BACKGROUND: The autophagy pathway has been linked with Crohn's disease (CD) through association of the ATG16L1 a …
T300A genetic polymorphism: a susceptibility factor for Crohn's disease?
Scolaro BL, dos Santos E, Ferreira LE, França PH, Kleinubing H Jr, Kotze PG, Pinho Mde S. Scolaro BL, et al. Arq Gastroenterol. 2014 Apr-Jun;51(2):97-101. doi: 10.1590/s0004-28032014000200005. Arq Gastroenterol. 2014. PMID: 25003259 Free article.
OBJECTIVES: Analyze the role of polymorphism T300A (rs2241880) in patients with Crohn's disease. ...CONCLUSIONS: It was not possible to confirm the increased susceptibility on development of Crohn's disease conferred …
OBJECTIVES: Analyze the role of polymorphism T300A (rs2241880) in patients with Crohn's disease. ...CONCLUSIONS: …
Association of a functional variant in the Wnt co-receptor LRP6 with early onset ileal Crohn's disease.
Koslowski MJ, Teltschik Z, Beisner J, Schaeffeler E, Wang G, Kübler I, Gersemann M, Cooney R, Jewell D, Reinisch W, Vermeire S, Rutgeerts P, Schwab M, Stange EF, Wehkamp J. Koslowski MJ, et al. PLoS Genet. 2012;8(2):e1002523. doi: 10.1371/journal.pgen.1002523. Epub 2012 Feb 23. PLoS Genet. 2012. PMID: 22393312 Free PMC article.
Ileal Crohn's Disease (CD), a chronic small intestinal inflammatory disorder, is characterized by reduced levels of the antimicrobial peptides DEFA5 (HD-5) and DEFA6 (HD-6). Both of these alpha-defensins are exclusively produced in Paneth cells (PCs) at small …
Ileal Crohn's Disease (CD), a chronic small intestinal inflammatory disorder, is characterized by reduced levels of the …
PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background.
Glas J, Wagner J, Seiderer J, Olszak T, Wetzke M, Beigel F, Tillack C, Stallhofer J, Friedrich M, Steib C, Göke B, Ochsenkühn T, Karbalai N, Diegelmann J, Czamara D, Brand S. Glas J, et al. PLoS One. 2012;7(3):e33682. doi: 10.1371/journal.pone.0033682. Epub 2012 Mar 21. PLoS One. 2012. PMID: 22457781 Free PMC article.
BACKGROUND: Genome-wide association studies identified PTPN2 (protein tyrosine phosphatase, non-receptor type 2) as susceptibility gene for inflammatory bowel diseases (IBD). However, the exact role of PTPN2 in Crohn's disease (CD) and ul …
BACKGROUND: Genome-wide association studies identified PTPN2 (protein tyrosine phosphatase, non-receptor type 2) as susceptibility
Among autophagy genes, ATG16L1 but not IRGM is associated with Crohn's disease in Iranians.
Teimoori-Toolabi L, Samadpoor S, Mehrtash A, Ghadir M, Vahedi H. Teimoori-Toolabi L, et al. Gene. 2018 Oct 30;675:176-184. doi: 10.1016/j.gene.2018.06.074. Epub 2018 Jun 28. Gene. 2018. PMID: 29960072
BACKGROUND: The prevalence of inflammatory bowel diseases is uprising in countries like Iran. Genetic predisposing elements play prominent role in the pathogenesis of Crohn's disease. In this study we studied the role of autophagy genes l …
BACKGROUND: The prevalence of inflammatory bowel diseases is uprising in countries like Iran. Genetic predisposing elements play prominent …
Evidence from genetics for a role of autophagy and innate immunity in IBD pathogenesis.
Parkes M. Parkes M. Dig Dis. 2012;30(4):330-3. doi: 10.1159/000338119. Epub 2012 Jul 12. Dig Dis. 2012. PMID: 22796792 Review.
The early identification of NOD2 (nucleotide-binding oligomerization domain-containing protein 2) as a susceptibility gene for Crohn's disease first catalysed major interest in the role of innate immunity in IBD. This interest has been su …
The early identification of NOD2 (nucleotide-binding oligomerization domain-containing protein 2) as a susceptibility gene for …
Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history.
Lees CW, Satsangi J. Lees CW, et al. Expert Rev Gastroenterol Hepatol. 2009 Oct;3(5):513-34. doi: 10.1586/egh.09.45. Expert Rev Gastroenterol Hepatol. 2009. PMID: 19817673 Review.
Epidemiological data, detailed molecular studies and recent genome-wide association studies strongly suggest that ulcerative colitis (UC) and Crohn's disease (CD) are related polygenic diseases that share some susceptibility loci, but differ at others. …
Epidemiological data, detailed molecular studies and recent genome-wide association studies strongly suggest that ulcerative colitis (UC) an …
Inflammatory bowel disease and colitis: new concepts from the bench and the clinic.
Vermeire S, Van Assche G, Rutgeerts P. Vermeire S, et al. Curr Opin Gastroenterol. 2011 Jan;27(1):32-7. doi: 10.1097/MOG.0b013e3283412e87. Curr Opin Gastroenterol. 2011. PMID: 21099431 Review.
Two of the genes, NOD2/CARD15 and the autophagy gene ATG16L1 have recently been linked into one functional pathway of bacterial sensing, invasion and elimination. ...SUMMARY: The recent findings in IBD include the increasing number of IBD susceptibility
Two of the genes, NOD2/CARD15 and the autophagy gene ATG16L1 have recently been linked into one functional pathway of b …
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