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Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B.
Congrains A, Kamide K, Oguro R, Yasuda O, Miyata K, Yamamoto E, Kawai T, Kusunoki H, Yamamoto H, Takeya Y, Yamamoto K, Onishi M, Sugimoto K, Katsuya T, Awata N, Ikebe K, Gondo Y, Oike Y, Ohishi M, Rakugi H. Congrains A, et al. Atherosclerosis. 2012 Feb;220(2):449-55. doi: 10.1016/j.atherosclerosis.2011.11.017. Epub 2011 Nov 19. Atherosclerosis. 2012. PMID: 22178423
A single nucleotide polymorphism of the adenosine deaminase, RNA-specific gene is associated with the serum triglyceride level, abdominal circumference, and serum adiponectin concentration.
Oguro R, Kamide K, Katsuya T, Akasaka H, Sugimoto K, Congrains A, Arai Y, Hirose N, Saitoh S, Ohishi M, Miura T, Rakugi H. Oguro R, et al. Among authors: congrains a. Exp Gerontol. 2012 Feb;47(2):183-7. doi: 10.1016/j.exger.2011.12.004. Epub 2011 Dec 22. Exp Gerontol. 2012. PMID: 22210125
Disease-associated polymorphisms in 9p21 are not associated with extreme longevity.
Congrains A, Kamide K, Hirose N, Arai Y, Oguro R, Nakama C, Imaizumi Y, Kawai T, Kusunoki H, Yamamoto H, Onishi-Takeya M, Takeya Y, Yamamoto K, Sugimoto K, Akasaka H, Saitoh S, Miura T, Awata N, Kato N, Katsuya T, Ikebe K, Gondo Y, Rakugi H. Congrains A, et al. Geriatr Gerontol Int. 2015 Jun;15(6):797-803. doi: 10.1111/ggi.12346. Epub 2014 Sep 26. Geriatr Gerontol Int. 2015. PMID: 25257646
A promoter polymorphism of lamin A/C gene is an independent genetic predisposition to arterial stiffness in a Japanese general population (the Tanno and Sobetsu study).
Akasaka H, Katsuya T, Saitoh S, Sugimoto K, Ohnishi H, Congrains A, Ohnishi M, Ohishi M, Rakugi H, Ogihara T, Shimamoto K. Akasaka H, et al. Among authors: congrains a. J Atheroscler Thromb. 2009 Aug;16(4):404-9. doi: 10.5551/jat.no1271. Epub 2009 Aug 11. J Atheroscler Thromb. 2009. PMID: 19672032 Free article.
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