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Your search for Connexis protect mouse pancreatic β cells against apoptosis retrieved no results
Connexins protect mouse pancreatic β cells against apoptosis.
Klee P, Allagnat F, Pontes H, Cederroth M, Charollais A, Caille D, Britan A, Haefliger JA, Meda P. Klee P, et al. J Clin Invest. 2011 Dec;121(12):4870-9. doi: 10.1172/JCI40509. Epub 2011 Nov 7. J Clin Invest. 2011. PMID: 22056383 Free PMC article.
Here, we show that connexin 36 (Cx36), a trans-membrane protein that forms gap junctions between β cells in the pancreatic islets, protects mouse β cells against both cytotoxic drugs and cytokines that prevail in the islet environment at …
Here, we show that connexin 36 (Cx36), a trans-membrane protein that forms gap junctions between β cells in the pancreatic
Glibenclamide Prevents Diabetes in NOD Mice.
Lamprianou S, Gysemans C, Bou Saab J, Pontes H, Mathieu C, Meda P. Lamprianou S, et al. PLoS One. 2016 Dec 22;11(12):e0168839. doi: 10.1371/journal.pone.0168839. eCollection 2016. PLoS One. 2016. PMID: 28006000 Free PMC article.
Previous work has revealed that Cx36, the sole connexin expressed in the insulin-producing beta cells, enhances the secretion of insulin, and promotes the resistance of beta cells against pro-inflammatory cytokines. ...We found tha …
Previous work has revealed that Cx36, the sole connexin expressed in the insulin-producing beta cells, enhances …
Reduction of connexin36 content by ICER-1 contributes to insulin-secreting cells apoptosis induced by oxidized LDL particles.
Haefliger JA, Martin D, Favre D, Petremand Y, Mazzolai L, Abderrahmani A, Meda P, Waeber G, Allagnat F. Haefliger JA, et al. PLoS One. 2013;8(1):e55198. doi: 10.1371/journal.pone.0055198. Epub 2013 Jan 30. PLoS One. 2013. PMID: 23383107 Free PMC article.
Connexin36 (Cx36), a trans-membrane protein that forms gap junctions between insulin-secreting beta-cells in the Langerhans islets, contributes to the proper control of insulin secretion and beta-cell survival. ...Cx36 knock-down in INS-1 …
Connexin36 (Cx36), a trans-membrane protein that forms gap junctions between insulin-secreting beta-cells in the …
Connexin36 contributes to INS-1E cells survival through modulation of cytokine-induced oxidative stress, ER stress and AMPK activity.
Allagnat F, Klee P, Cardozo AK, Meda P, Haefliger JA. Allagnat F, et al. Cell Death Differ. 2013 Dec;20(12):1742-52. doi: 10.1038/cdd.2013.134. Epub 2013 Oct 4. Cell Death Differ. 2013. PMID: 24096873 Free PMC article.
Using specific Cx36 siRNAs or adenoviral vectors, we now show that Cx36 downregulation promotes apoptosis in INS-1E cells exposed to the pro-inflammatory cytokines (IL-1β, TNF-α and IFN-γ) involved at the onset of type 1 diabetes, whereas Cx36 overexpression prot
Using specific Cx36 siRNAs or adenoviral vectors, we now show that Cx36 downregulation promotes apoptosis in INS-1E cells expo …
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