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Riociguat: first global approval.
Conole D, Scott LJ. Conole D, et al. Drugs. 2013 Nov;73(17):1967-75. doi: 10.1007/s40265-013-0149-5. Drugs. 2013. PMID: 24218053
Colistimethate sodium dry powder for inhalation: a review of its use in the treatment of chronic Pseudomonas aeruginosa infection in patients with cystic fibrosis.
Conole D, Keating GM. Conole D, et al. Drugs. 2014 Mar;74(3):377-87. doi: 10.1007/s40265-014-0181-0. Drugs. 2014. PMID: 24510624 Review.
6-Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis.
Tong AST, Choi PJ, Blaser A, Sutherland HS, Tsang SKY, Guillemont J, Motte M, Cooper CB, Andries K, Van den Broeck W, Franzblau SG, Upton AM, Denny WA, Palmer BD, Conole D. Tong AST, et al. Among authors: conole d. ACS Med Chem Lett. 2017 Sep 22;8(10):1019-1024. doi: 10.1021/acsmedchemlett.7b00196. eCollection 2017 Oct 12. ACS Med Chem Lett. 2017. PMID: 29057044 Free PMC article.
Prodrugs of N-dicarboximide derivatives of the rat selective toxicant norbormide.
Rennison D, Laita O, Conole D, Jay-Smith M, Knauf J, Bova S, Cavalli M, Hopkins B, Linthicum DS, Brimble MA. Rennison D, et al. Among authors: conole d. Bioorg Med Chem. 2013 Sep 15;21(18):5886-99. doi: 10.1016/j.bmc.2013.06.071. Epub 2013 Jul 10. Bioorg Med Chem. 2013. PMID: 23920483
Synthesis and methemoglobinemia-inducing properties of analogues of para-aminopropiophenone designed as humane rodenticides.
Rennison D, Conole D, Tingle MD, Yang J, Eason CT, Brimble MA. Rennison D, et al. Among authors: conole d. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6629-35. doi: 10.1016/j.bmcl.2013.10.046. Epub 2013 Oct 31. Bioorg Med Chem Lett. 2013. PMID: 24210502
Synthesis and methemoglobinemia-inducing properties of benzocaine isosteres designed as humane rodenticides.
Conole D, Beck TM, Jay-Smith M, Tingle MD, Eason CT, Brimble MA, Rennison D. Conole D, et al. Bioorg Med Chem. 2014 Apr 1;22(7):2220-35. doi: 10.1016/j.bmc.2014.02.013. Epub 2014 Feb 20. Bioorg Med Chem. 2014. PMID: 24602400
3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel.
Sutherland HS, Tong AST, Choi PJ, Blaser A, Conole D, Franzblau SG, Lotlikar MU, Cooper CB, Upton AM, Denny WA, Palmer BD. Sutherland HS, et al. Among authors: conole d. Bioorg Med Chem. 2019 Apr 1;27(7):1292-1307. doi: 10.1016/j.bmc.2019.02.026. Epub 2019 Feb 15. Bioorg Med Chem. 2019. PMID: 30803745 Free PMC article.
Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline.
Blaser A, Sutherland HS, Tong AST, Choi PJ, Conole D, Franzblau SG, Cooper CB, Upton AM, Lotlikar M, Denny WA, Palmer BD. Blaser A, et al. Among authors: conole d. Bioorg Med Chem. 2019 Apr 1;27(7):1283-1291. doi: 10.1016/j.bmc.2019.02.025. Epub 2019 Feb 15. Bioorg Med Chem. 2019. PMID: 30792104 Free PMC article.
Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles.
Sutherland HS, Tong AST, Choi PJ, Conole D, Blaser A, Franzblau SG, Cooper CB, Upton AM, Lotlikar MU, Denny WA, Palmer BD. Sutherland HS, et al. Among authors: conole d. Bioorg Med Chem. 2018 May 1;26(8):1797-1809. doi: 10.1016/j.bmc.2018.02.026. Epub 2018 Feb 20. Bioorg Med Chem. 2018. PMID: 29482950 Free PMC article.
Fatty Acid-Derived Pro-Toxicants of the Rat Selective Toxicant Norbormide.
Choi H, Conole D, Atkinson DJ, Laita O, Jay-Smith M, Pagano MA, Ribaudo G, Cavalli M, Bova S, Hopkins B, Brimble MA, Rennison D. Choi H, et al. Among authors: conole d. Chem Biodivers. 2016 Jun;13(6):762-75. doi: 10.1002/cbdv.201500241. Epub 2016 Jun 2. Chem Biodivers. 2016. PMID: 27144301
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