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Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain.
Estevam GO, Linossi EM, Macdonald CB, Espinoza CA, Michaud JM, Coyote-Maestas W, Collisson EA, Jura N, Fraser JS. Estevam GO, et al. Elife. 2024 Sep 13;12:RP91619. doi: 10.7554/eLife.91619. Elife. 2024. PMID: 39268701 Free PMC article.
Mutations, which are predominantly observed clinically in the intracellular juxtamembrane and kinase domains, can disrupt typical MET regulatory mechanisms. ...Here, we perform a parallel deep mutational scan (DMS) of the …
Mutations, which are predominantly observed clinically in the intracellular juxtamembrane and kinase domains, ca …
Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain.
Estevam GO, Linossi EM, Macdonald CB, Espinoza CA, Michaud JM, Coyote-Maestas W, Collisson EA, Jura N, Fraser JS. Estevam GO, et al. bioRxiv [Preprint]. 2024 May 6:2023.08.03.551866. doi: 10.1101/2023.08.03.551866. bioRxiv. 2024. Update in: Elife. 2024 Sep 13;12:RP91619. doi: 10.7554/eLife.91619. PMID: 37577651 Free PMC article. Updated. Preprint.
Mutations, which are predominantly observed clinically in the intracellular juxtamembrane and kinase domains, can disrupt typical MET regulatory mechanisms. ...Here, we perform a parallel deep mutational scan (DMS) of the …
Mutations, which are predominantly observed clinically in the intracellular juxtamembrane and kinase domains, ca …