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Dipeptide derivatives of primaquine as transmission-blocking antimalarials: effect of aliphatic side-chain acylation on the gametocytocidal activity and on the formation of carboxyprimaquine in rat liver homogenates.
Portela MJ, Moreira R, Valente E, Constantino L, Iley J, Pinto J, Rosa R, Cravo P, do Rosário VE. Portela MJ, et al. Among authors: constantino l. Pharm Res. 1999 Jun;16(6):949-55. doi: 10.1023/a:1018922425551. Pharm Res. 1999. PMID: 10397619
The microsomal dealkylation of N,N-dialkylbenzamides.
Iley J, Constantino L. Iley J, et al. Among authors: constantino l. Biochem Pharmacol. 1994 Jan 20;47(2):275-80. doi: 10.1016/0006-2952(94)90017-5. Biochem Pharmacol. 1994. PMID: 8304971
Esters of Pyrazinoic Acid Are Active against Pyrazinamide-Resistant Strains of Mycobacterium tuberculosis and Other Naturally Resistant Mycobacteria In Vitro and Ex Vivo within Macrophages.
Pires D, Valente E, Simões MF, Carmo N, Testa B, Constantino L, Anes E. Pires D, et al. Among authors: constantino l. Antimicrob Agents Chemother. 2015 Dec;59(12):7693-9. doi: 10.1128/AAC.00936-15. Epub 2015 Oct 5. Antimicrob Agents Chemother. 2015. PMID: 26438493 Free PMC article.
In previous work, we have shown that POA esters and amides synthesized in our laboratory were stable in plasma (M. F. Simoes, E. Valente, M. J. Gomez, E. Anes, and L. Constantino, Eur J Pharm Sci 37:257-263, 2009, http://dx.doi.org/10.1016/j.ejps.2009.02.012). ...
In previous work, we have shown that POA esters and amides synthesized in our laboratory were stable in plasma (M. F. Simoes, E. Valente, M. …
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