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Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis.
Machado D, Couto I, Perdigão J, Rodrigues L, Portugal I, Baptista P, Veigas B, Amaral L, Viveiros M. Machado D, et al. PLoS One. 2012;7(4):e34538. doi: 10.1371/journal.pone.0034538. Epub 2012 Apr 6. PLoS One. 2012. PMID: 22493700 Free PMC article.
Multidrug resistant (MDR) tuberculosis is caused by Mycobacterium tuberculosis resistant to isoniazid and rifampicin, the two most effective drugs used in tuberculosis therapy. ...Together, results demonstrate the relevance of efflux
Multidrug resistant (MDR) tuberculosis is caused by Mycobacterium tuberculosis resistant to isoniazid and
Expression analysis of 10 efflux pump genes in multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis clinical isolates.
Kardan-Yamchi J, Kazemian H, Haeili M, Harati AA, Amini S, Feizabadi MM. Kardan-Yamchi J, et al. J Glob Antimicrob Resist. 2019 Jun;17:201-208. doi: 10.1016/j.jgar.2019.01.003. Epub 2019 Jan 14. J Glob Antimicrob Resist. 2019. PMID: 30654147
OBJECTIVES: Active extrusion of antituberculosis drugs via efflux pumps (EPs) has been suggested as contributing to drug resistance in Mycobacterium tuberculosis. This study was conducted to determine the role of 10 drug efflux
OBJECTIVES: Active extrusion of antituberculosis drugs via efflux pumps (EPs) has been suggested as contributing to drug