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The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways.
Conway EM, Van de Wouwer M, Pollefeyt S, Jurk K, Van Aken H, De Vriese A, Weitz JI, Weiler H, Hellings PW, Schaeffer P, Herbert JM, Collen D, Theilmeier G. Conway EM, et al. J Exp Med. 2002 Sep 2;196(5):565-77. doi: 10.1084/jem.20020077. J Exp Med. 2002. PMID: 12208873 Free PMC article.
Novel functions of thrombomodulin in inflammation.
Van de Wouwer M, Conway EM. Van de Wouwer M, et al. Among authors: conway em. Crit Care Med. 2004 May;32(5 Suppl):S254-61. doi: 10.1097/01.ccm.0000128036.64448.9e. Crit Care Med. 2004. PMID: 15118527 Review.
Thrombomodulin mutations in atypical hemolytic-uremic syndrome.
Delvaeye M, Noris M, De Vriese A, Esmon CT, Esmon NL, Ferrell G, Del-Favero J, Plaisance S, Claes B, Lambrechts D, Zoja C, Remuzzi G, Conway EM. Delvaeye M, et al. Among authors: conway em. N Engl J Med. 2009 Jul 23;361(4):345-57. doi: 10.1056/NEJMoa0810739. N Engl J Med. 2009. PMID: 19625716 Free PMC article.
169 results