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Ethanol, not detectably metabolized in brain, significantly reduces brain metabolism, probably via action at specific GABA(A) receptors and has measureable metabolic effects at very low concentrations.
Rae CD, Davidson JE, Maher AD, Rowlands BD, Kashem MA, Nasrallah FA, Rallapalli SK, Cook JM, Balcar VJ. Rae CD, et al. Among authors: cook jm. J Neurochem. 2014 Apr;129(2):304-14. doi: 10.1111/jnc.12634. Epub 2013 Dec 18. J Neurochem. 2014. PMID: 24313287 Free PMC article.
A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis.
Han D, Holger Försterling F, Li X, Deschamps JR, Parrish D, Cao H, Rallapalli S, Clayton T, Teng Y, Majumder S, Sankar S, Roth BL, Sieghart W, Furtmuller R, Rowlett JK, Weed MR, Cook JM. Han D, et al. Among authors: cook jm. Bioorg Med Chem. 2008 Oct 1;16(19):8853-62. doi: 10.1016/j.bmc.2008.08.072. Epub 2008 Sep 2. Bioorg Med Chem. 2008. PMID: 18790643 Free PMC article.
The differential role of alpha1- and alpha5-containing GABA(A) receptors in mediating diazepam effects on spontaneous locomotor activity and water-maze learning and memory in rats.
Savić MM, Milinković MM, Rallapalli S, Clayton T Sr, Joksimović S, Van Linn M, Cook JM. Savić MM, et al. Among authors: cook jm. Int J Neuropsychopharmacol. 2009 Oct;12(9):1179-93. doi: 10.1017/S1461145709000108. Epub 2009 Mar 6. Int J Neuropsychopharmacol. 2009. PMID: 19265570 Free PMC article.
612 results