Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity

Toxicon. 1988;26(8):750-3. doi: 10.1016/0041-0101(88)90282-6.

Abstract

Anatoxin-a(s), an alkaloid neurotoxin from the freshwater cyanobacterium, Anabaena flos-aquae NRC-525-17, was compared to paraoxon, physostigmine and pyridostigmine for effects on brain cholinesterase after i.p. injection into Balb/c mice. The duration of clinical signs in mice injected with anatoxin-a(s) persisted longer than in mice given the carbamates and was comparable with that of paraoxon. Anatoxin-a(s) did not inhibit brain cholinesterase activity suggesting that this toxin is unable to cross the blood-brain barrier.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Bacterial Toxins*
  • Brain / enzymology
  • Cholinesterase Inhibitors / pharmacology*
  • Cholinesterases / metabolism
  • Cyanobacteria Toxins
  • Lethal Dose 50
  • Male
  • Marine Toxins / pharmacology*
  • Mice
  • Mice, Inbred BALB C
  • Microcystins
  • Paraoxon / pharmacology*
  • Physostigmine / pharmacology*
  • Pyridostigmine Bromide / pharmacology*
  • Rats
  • Tropanes

Substances

  • Bacterial Toxins
  • Cholinesterase Inhibitors
  • Cyanobacteria Toxins
  • Marine Toxins
  • Microcystins
  • Tropanes
  • anatoxin a
  • Physostigmine
  • Cholinesterases
  • Pyridostigmine Bromide
  • Paraoxon