Abstract
Anatoxin-a(s), an alkaloid neurotoxin from the freshwater cyanobacterium, Anabaena flos-aquae NRC-525-17, was compared to paraoxon, physostigmine and pyridostigmine for effects on brain cholinesterase after i.p. injection into Balb/c mice. The duration of clinical signs in mice injected with anatoxin-a(s) persisted longer than in mice given the carbamates and was comparable with that of paraoxon. Anatoxin-a(s) did not inhibit brain cholinesterase activity suggesting that this toxin is unable to cross the blood-brain barrier.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Bacterial Toxins*
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Brain / enzymology
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Cholinesterase Inhibitors / pharmacology*
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Cholinesterases / metabolism
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Cyanobacteria Toxins
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Lethal Dose 50
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Male
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Marine Toxins / pharmacology*
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Mice
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Mice, Inbred BALB C
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Microcystins
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Paraoxon / pharmacology*
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Physostigmine / pharmacology*
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Pyridostigmine Bromide / pharmacology*
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Rats
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Tropanes
Substances
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Bacterial Toxins
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Cholinesterase Inhibitors
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Cyanobacteria Toxins
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Marine Toxins
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Microcystins
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Tropanes
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anatoxin a
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Physostigmine
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Cholinesterases
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Pyridostigmine Bromide
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Paraoxon