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Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation.
Liszewski MK, Kolev M, Le Friec G, Leung M, Bertram PG, Fara AF, Subias M, Pickering MC, Drouet C, Meri S, Arstila TP, Pekkarinen PT, Ma M, Cope A, Reinheckel T, Rodriguez de Cordoba S, Afzali B, Atkinson JP, Kemper C. Liszewski MK, et al. Among authors: cope a. Immunity. 2013 Dec 12;39(6):1143-57. doi: 10.1016/j.immuni.2013.10.018. Epub 2013 Dec 5. Immunity. 2013. PMID: 24315997 Free PMC article.
The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells.
Perucha E, Melchiotti R, Bibby JA, Wu W, Frederiksen KS, Roberts CA, Hall Z, LeFriec G, Robertson KA, Lavender P, Gerwien JG, Taams LS, Griffin JL, de Rinaldis E, van Baarsen LGM, Kemper C, Ghazal P, Cope AP. Perucha E, et al. Among authors: cope ap. Nat Commun. 2019 Jan 30;10(1):498. doi: 10.1038/s41467-019-08332-9. Nat Commun. 2019. PMID: 30700717 Free PMC article.
Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events.
Sobolev O, Binda E, O'Farrell S, Lorenc A, Pradines J, Huang Y, Duffner J, Schulz R, Cason J, Zambon M, Malim MH, Peakman M, Cope A, Capila I, Kaundinya GV, Hayday AC. Sobolev O, et al. Among authors: cope a. Nat Immunol. 2016 Feb;17(2):204-13. doi: 10.1038/ni.3328. Epub 2016 Jan 4. Nat Immunol. 2016. PMID: 26726811 Free PMC article.
T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells.
Arbore G, West EE, Spolski R, Robertson AAB, Klos A, Rheinheimer C, Dutow P, Woodruff TM, Yu ZX, O'Neill LA, Coll RC, Sher A, Leonard WJ, Köhl J, Monk P, Cooper MA, Arno M, Afzali B, Lachmann HJ, Cope AP, Mayer-Barber KD, Kemper C. Arbore G, et al. Among authors: cope ap. Science. 2016 Jun 17;352(6292):aad1210. doi: 10.1126/science.aad1210. Science. 2016. PMID: 27313051 Free PMC article.
LFA-1 in T cell priming, differentiation, and effector functions.
Gérard A, Cope AP, Kemper C, Alon R, Köchl R. Gérard A, et al. Among authors: cope ap. Trends Immunol. 2021 Aug;42(8):706-722. doi: 10.1016/j.it.2021.06.004. Epub 2021 Jul 12. Trends Immunol. 2021. PMID: 34266767 Free PMC article. Review.
Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells.
Kolev M, West EE, Kunz N, Chauss D, Moseman EA, Rahman J, Freiwald T, Balmer ML, Lötscher J, Dimeloe S, Rosser EC, Wedderburn LR, Mayer-Barber KD, Bohrer A, Lavender P, Cope A, Wang L, Kaplan MJ, Moutsopoulos NM, McGavern D, Holland SM, Hess C, Kazemian M, Afzali B, Kemper C. Kolev M, et al. Among authors: cope a. Immunity. 2020 Mar 17;52(3):513-527.e8. doi: 10.1016/j.immuni.2020.02.006. Immunity. 2020. PMID: 32187519 Free PMC article.
440 results