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Year Number of Results
1792 1
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1827 1
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1842 2
1843 1
1844 2
1845 2
1847 2
1848 1
1852 1
1853 1
1854 2
1855 1
1856 1
1858 1
1861 1
1870 4
1876 1
1879 1
1880 1
1881 2
1883 4
1884 1
1885 3
1886 2
1887 2
1888 2
1889 4
1891 5
1892 7
1893 1
1894 1
1896 1
1897 1
1902 1
1903 1
1904 1
1905 12
1907 3
1908 2
1909 1
1911 1
1913 1
1914 5
1915 2
1917 1
1919 1
1920 2
1921 2
1922 3
1924 3
1925 8
1926 7
1927 6
1928 1
1929 4
1930 8
1931 15
1932 6
1933 6
1934 7
1935 5
1936 4
1937 6
1938 4
1939 6
1940 4
1941 8
1942 4
1943 4
1944 2
1945 26
1946 64
1947 63
1948 83
1949 56
1950 100
1951 109
1952 100
1953 124
1954 106
1955 132
1956 117
1957 151
1958 130
1959 107
1960 123
1961 173
1962 191
1963 305
1964 426
1965 392
1966 427
1967 549
1968 681
1969 734
1970 725
1971 742
1972 818
1973 866
1974 929
1975 938
1976 951
1977 893
1978 938
1979 1039
1980 1053
1981 1072
1982 975
1983 1114
1984 1088
1985 1167
1986 1208
1987 1217
1988 1232
1989 1359
1990 1356
1991 1384
1992 1412
1993 1413
1994 1454
1995 1629
1996 1676
1997 1605
1998 1752
1999 1847
2000 2176
2001 2548
2002 2613
2003 2868
2004 3259
2005 3654
2006 3991
2007 4363
2008 4686
2009 4673
2010 4996
2011 5629
2012 5773
2013 6083
2014 6432
2015 6761
2016 6605
2017 6632
2018 7181
2019 7926
2020 8389
2021 8757
2022 9183
2023 9350
2024 9485
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169,959 results

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Page 1
Copper: effects of deficiency and overload.
Scheiber I, Dringen R, Mercer JF. Scheiber I, et al. Met Ions Life Sci. 2013;13:359-87. doi: 10.1007/978-94-007-7500-8_11. Met Ions Life Sci. 2013. PMID: 24470097 Free article. Review.
However, since an excess of copper can also harm cells due to its potential to catalyze the generation of toxic reactive oxygen species, transport of copper and the cellular copper content are tightly regulated. ...In addition, we will give an overview on dis …
However, since an excess of copper can also harm cells due to its potential to catalyze the generation of toxic reactive oxygen speci …
Copper-induced cell death.
Kahlson MA, Dixon SJ. Kahlson MA, et al. Science. 2022 Mar 18;375(6586):1231-1232. doi: 10.1126/science.abo3959. Epub 2022 Mar 17. Science. 2022. PMID: 35298241
Excess copper causes mitochondrial protein aggregation and triggers a distinct form of cell death....
Excess copper causes mitochondrial protein aggregation and triggers a distinct form of cell death....
Copper-induced tumor cell death mechanisms and antitumor theragnostic applications of copper complexes.
Jiang Y, Huo Z, Qi X, Zuo T, Wu Z. Jiang Y, et al. Nanomedicine (Lond). 2022 Feb;17(5):303-324. doi: 10.2217/nnm-2021-0374. Epub 2022 Jan 21. Nanomedicine (Lond). 2022. PMID: 35060391 Review.
This review first highlights three typical forms of copper's antitumor mechanisms. Then, the development of diverse biomaterials and nanotechnology allowing copper to be fabricated into diverse structures to realize its theragnostic action is discussed. Novel …
This review first highlights three typical forms of copper's antitumor mechanisms. Then, the development of diverse biomateria …
Elesclomol, a copper-transporting therapeutic agent targeting mitochondria: from discovery to its novel applications.
Tarin M, Babaie M, Eshghi H, Matin MM, Saljooghi AS. Tarin M, et al. J Transl Med. 2023 Oct 20;21(1):745. doi: 10.1186/s12967-023-04533-5. J Transl Med. 2023. PMID: 37864163 Free PMC article. Review.
Copper (Cu) is an essential element that is involved in a variety of biochemical processes. ...The production of reactive oxygen species (ROS), oxidative stress, and cuproptosis are among the proposed mechanisms of copper toxicity at high concentrations. Elesclomol …
Copper (Cu) is an essential element that is involved in a variety of biochemical processes. ...The production of reactive oxygen spec …
Harnessing nanomaterials for copper-induced cell death.
Li SR, Tao SY, Li Q, Hu CY, Sun ZJ. Li SR, et al. Biomaterials. 2025 Feb;313:122805. doi: 10.1016/j.biomaterials.2024.122805. Epub 2024 Sep 3. Biomaterials. 2025. PMID: 39250865 Review.
The emergence of nanodrug delivery systems, distinguished by their precise targeting, controlled release, high payload capacity, and the ability to co-deliver multiple agents, has revitalized interest in exploiting copper's precise regulatory capabilities. Neverthel …
The emergence of nanodrug delivery systems, distinguished by their precise targeting, controlled release, high payload capacity, and the abi …
Copper.
Barceloux DG. Barceloux DG. J Toxicol Clin Toxicol. 1999;37(2):217-30. doi: 10.1081/clt-100102421. J Toxicol Clin Toxicol. 1999. PMID: 10382557 Review.
Following zinc and iron, copper is the third most abundant trace element in the body. Copper is a noble metal, like silver and gold. Useful industrial properties include high thermal and electrical conductivity, low corrosion, alloying ability, and malleability. Mos …
Following zinc and iron, copper is the third most abundant trace element in the body. Copper is a noble metal, like silver and …
APEX2-based Proximity Labeling of Atox1 Identifies CRIP2 as a Nuclear Copper-binding Protein that Regulates Autophagy Activation.
Chen L, Li N, Zhang M, Sun M, Bian J, Yang B, Li Z, Wang J, Li F, Shi X, Wang Y, Yuan F, Zou P, Shan C, Wang J. Chen L, et al. Angew Chem Int Ed Engl. 2021 Nov 22;60(48):25346-25355. doi: 10.1002/anie.202108961. Epub 2021 Oct 27. Angew Chem Int Ed Engl. 2021. PMID: 34550632
Mammalian cell nuclei contain copper, and cancer cells are known to accumulate aberrantly high copper levels, yet the mechanisms underlying nuclear accumulation and copper's broader functional significance remain poorly understood. Here, by combining A …
Mammalian cell nuclei contain copper, and cancer cells are known to accumulate aberrantly high copper levels, yet the mechanis …
Cope with copper: From copper linked mechanisms to copper-based clinical cancer therapies.
Wang X, Zhou M, Liu Y, Si Z. Wang X, et al. Cancer Lett. 2023 May 1;561:216157. doi: 10.1016/j.canlet.2023.216157. Epub 2023 Apr 1. Cancer Lett. 2023. PMID: 37011869 Review.
Interestingly, strong redox-active properties make copper both beneficial and detrimental to cancer cells. Cuproplasia is copper-dependent cell growth and proliferation, whereas cuproptosis is copper-dependent cell death. ...In this review, we summarized the …
Interestingly, strong redox-active properties make copper both beneficial and detrimental to cancer cells. Cuproplasia is copper …
The promise of copper ionophores as antimicrobials.
O'Brien H, Davoodian T, Johnson MDL. O'Brien H, et al. Curr Opin Microbiol. 2023 Oct;75:102355. doi: 10.1016/j.mib.2023.102355. Epub 2023 Jul 3. Curr Opin Microbiol. 2023. PMID: 37406562 Free PMC article. Review.
Unfortunately, due to microbial adaptation to develop resistance, some antibiotics are nullified early in their usage, and worse, resistance is detected before they can even be prescribed. Copper's toxicity since antiquity against microbes at the host-pathogen inter …
Unfortunately, due to microbial adaptation to develop resistance, some antibiotics are nullified early in their usage, and worse, resistance …
169,959 results
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