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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1792 1
1802 1
1827 1
1837 1
1842 2
1843 1
1844 2
1845 2
1847 2
1848 1
1852 1
1853 1
1854 2
1855 1
1856 1
1858 1
1861 1
1870 4
1876 1
1879 1
1880 1
1881 2
1883 4
1884 1
1885 3
1886 2
1887 2
1888 2
1889 4
1891 5
1892 7
1893 1
1894 1
1896 1
1897 1
1902 1
1903 1
1904 1
1905 11
1907 3
1908 2
1909 1
1911 1
1913 1
1914 5
1915 2
1917 1
1919 1
1920 2
1921 2
1922 3
1924 3
1925 8
1926 7
1927 6
1928 1
1929 4
1930 8
1931 15
1932 6
1933 6
1934 7
1935 5
1936 4
1937 6
1938 4
1939 6
1940 4
1941 8
1942 4
1943 4
1944 2
1945 23
1946 58
1947 52
1948 75
1949 50
1950 80
1951 87
1952 74
1953 100
1954 86
1955 114
1956 90
1957 128
1958 114
1959 96
1960 106
1961 151
1962 171
1963 286
1964 380
1965 259
1966 218
1967 234
1968 285
1969 302
1970 272
1971 286
1972 331
1973 329
1974 350
1975 552
1976 611
1977 588
1978 628
1979 739
1980 759
1981 762
1982 690
1983 862
1984 802
1985 882
1986 917
1987 906
1988 957
1989 1055
1990 1069
1991 1063
1992 1088
1993 1139
1994 1145
1995 1242
1996 1359
1997 1258
1998 1409
1999 1461
2000 1712
2001 2063
2002 2111
2003 2317
2004 2637
2005 2921
2006 3110
2007 3416
2008 3758
2009 3716
2010 3945
2011 4450
2012 4592
2013 4862
2014 5395
2015 5690
2016 5744
2017 5859
2018 6334
2019 7014
2020 7476
2021 7992
2022 8406
2023 8764
2024 7131
2025 20

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137,714 results

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Page 1
Copper: effects of deficiency and overload.
Scheiber I, Dringen R, Mercer JF. Scheiber I, et al. Met Ions Life Sci. 2013;13:359-87. doi: 10.1007/978-94-007-7500-8_11. Met Ions Life Sci. 2013. PMID: 24470097 Free article. Review.
However, since an excess of copper can also harm cells due to its potential to catalyze the generation of toxic reactive oxygen species, transport of copper and the cellular copper content are tightly regulated. ...In addition, we will give an overview on dis …
However, since an excess of copper can also harm cells due to its potential to catalyze the generation of toxic reactive oxygen speci …
Copper deficiency anemia: review article.
Myint ZW, Oo TH, Thein KZ, Tun AM, Saeed H. Myint ZW, et al. Ann Hematol. 2018 Sep;97(9):1527-1534. doi: 10.1007/s00277-018-3407-5. Epub 2018 Jun 29. Ann Hematol. 2018. PMID: 29959467 Review.
Detailed pathophysiology and its related diseases are explained in this manuscript. Diagnosis is made by measuring serum copper, serum ceruloplasmin, and 24-h urine copper levels. Copper deficiency anemia is treated with oral or intravenous copper repl …
Detailed pathophysiology and its related diseases are explained in this manuscript. Diagnosis is made by measuring serum copper, seru …
Copper and Diabetes: Current Research and Prospect.
Chang W, Li P. Chang W, et al. Mol Nutr Food Res. 2023 Dec;67(23):e2300468. doi: 10.1002/mnfr.202300468. Epub 2023 Oct 20. Mol Nutr Food Res. 2023. PMID: 37863813 Review.
Copper is an essential trace metal for normal cellular functions; a lack of copper is reported to impair the function of important copper-binding enzymes, while excess copper could lead to cell death. ...This review summarizes the precise and tight reg …
Copper is an essential trace metal for normal cellular functions; a lack of copper is reported to impair the function of impor …
The Role of Copper Homeostasis in Brain Disease.
An Y, Li S, Huang X, Chen X, Shan H, Zhang M. An Y, et al. Int J Mol Sci. 2022 Nov 10;23(22):13850. doi: 10.3390/ijms232213850. Int J Mol Sci. 2022. PMID: 36430330 Free PMC article. Review.
Copper is naturally present in some foods and is available as a dietary supplement. Only small amounts of copper are typically stored in the body and a large amount of copper is excreted through bile and urine. Given the critical role of copper in a br …
Copper is naturally present in some foods and is available as a dietary supplement. Only small amounts of copper are typically …
FDX1-dependent and independent mechanisms of elesclomol-mediated intracellular copper delivery.
Zulkifli M, Spelbring AN, Zhang Y, Soma S, Chen S, Li L, Le T, Shanbhag V, Petris MJ, Chen TY, Ralle M, Barondeau DP, Gohil VM. Zulkifli M, et al. Proc Natl Acad Sci U S A. 2023 Mar 7;120(10):e2216722120. doi: 10.1073/pnas.2216722120. Epub 2023 Feb 27. Proc Natl Acad Sci U S A. 2023. PMID: 36848556 Free PMC article.
Thus, ES-mediated copper delivery to nonmitochondrial cuproproteins continues even in the absence of FDX1, suggesting alternate mechanism(s) of copper release. Importantly, we demonstrate that this mechanism of copper transport by ES is distinct from other cl …
Thus, ES-mediated copper delivery to nonmitochondrial cuproproteins continues even in the absence of FDX1, suggesting alternate mecha …
Neurotoxicity of Copper.
Bulcke F, Dringen R, Scheiber IF. Bulcke F, et al. Adv Neurobiol. 2017;18:313-343. doi: 10.1007/978-3-319-60189-2_16. Adv Neurobiol. 2017. PMID: 28889275 Review.
Therefore, systemic and cellular copper homeostasis is tightly regulated, but dysregulation of copper homeostasis may occur in disease states, resulting either in copper deficiency or copper overload and toxicity. This chapter will give an overview on …
Therefore, systemic and cellular copper homeostasis is tightly regulated, but dysregulation of copper homeostasis may occur in …
Canine Copper-Associated Hepatitis.
Dirksen K, Fieten H. Dirksen K, et al. Vet Clin North Am Small Anim Pract. 2017 May;47(3):631-644. doi: 10.1016/j.cvsm.2016.11.011. Epub 2017 Jan 5. Vet Clin North Am Small Anim Pract. 2017. PMID: 28063745 Review.
The only way to establish the diagnosis is by histologic assessment of copper distribution and copper quantification in a liver biopsy. Treatment with the copper chelator d-penicillamine is the most commonly used treatment. In addition, a low-copper/hi …
The only way to establish the diagnosis is by histologic assessment of copper distribution and copper quantification in a live …
Copper Toxicity.
Royer A, Sharman T. Royer A, et al. 2023 Mar 27. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Mar 27. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 32491388 Free Books & Documents.
However, because of their size, bone and muscle contain more than half of the copper in the body. Copper is bound to ceruloplasmin in the liver, which transports the copper from the liver to the peripheral tissues. ...Copperiedus (copper toxicity) can …
However, because of their size, bone and muscle contain more than half of the copper in the body. Copper is bound to cerulopla …
Mitochondrial copper in human genetic disorders.
Garza NM, Swaminathan AB, Maremanda KP, Zulkifli M, Gohil VM. Garza NM, et al. Trends Endocrinol Metab. 2023 Jan;34(1):21-33. doi: 10.1016/j.tem.2022.11.001. Epub 2022 Nov 23. Trends Endocrinol Metab. 2023. PMID: 36435678 Free PMC article. Review.
Copper enters cells through a dedicated copper transporter and is distributed to intracellular cuproenzymes by copper chaperones. ...Mutations in copper transporters and chaperones that perturb mitochondrial copper homeostasis result in fatal ge …
Copper enters cells through a dedicated copper transporter and is distributed to intracellular cuproenzymes by copper c …
Bacterial copper storage proteins.
Dennison C, David S, Lee J. Dennison C, et al. J Biol Chem. 2018 Mar 30;293(13):4616-4627. doi: 10.1074/jbc.TM117.000180. Epub 2018 Feb 6. J Biol Chem. 2018. PMID: 29414794 Free PMC article. Review.
Copper is essential for most organisms as a cofactor for key enzymes involved in fundamental processes such as respiration and photosynthesis. However, copper also has toxic effects in cells, which is why eukaryotes and prokaryotes have evolved mechanisms for safe …
Copper is essential for most organisms as a cofactor for key enzymes involved in fundamental processes such as respiration and photos …
137,714 results
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