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Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis.
Gopinathan L, Tan SL, Padmakumar VC, Coppola V, Tessarollo L, Kaldis P. Gopinathan L, et al. Among authors: Coppola V. Cancer Res. 2014 Jul 15;74(14):3870-9. doi: 10.1158/0008-5472.CAN-13-3440. Epub 2014 May 6. Cancer Res. 2014. PMID: 24802190 Free PMC article.
Cdk2 knockout mice are viable.
Berthet C, Aleem E, Coppola V, Tessarollo L, Kaldis P. Berthet C, et al. Among authors: Coppola V. Curr Biol. 2003 Oct 14;13(20):1775-85. doi: 10.1016/j.cub.2003.09.024. Curr Biol. 2003. PMID: 14561402
Ablation of TrkA function in the immune system causes B cell abnormalities.
Coppola V, Barrick CA, Southon EA, Celeste A, Wang K, Chen B, Haddad el-B, Yin J, Nussenzweig A, Subramaniam A, Tessarollo L. Coppola V, et al. Development. 2004 Oct;131(20):5185-95. doi: 10.1242/dev.01383. Development. 2004. PMID: 15459109
RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis.
Satyanarayana A, Gudmundsson KO, Chen X, Coppola V, Tessarollo L, Keller JR, Hou SX. Satyanarayana A, et al. Among authors: Coppola V. Blood. 2010 Oct 21;116(16):2921-31. doi: 10.1182/blood-2010-01-262964. Epub 2010 Jul 1. Blood. 2010. PMID: 20595512 Free PMC article.
Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration.
Diril MK, Ratnacaram CK, Padmakumar VC, Du T, Wasser M, Coppola V, Tessarollo L, Kaldis P. Diril MK, et al. Among authors: Coppola V. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3826-31. doi: 10.1073/pnas.1115201109. Epub 2012 Feb 21. Proc Natl Acad Sci U S A. 2012. PMID: 22355113 Free PMC article.
IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice.
Hodge DL, Berthet C, Coppola V, Kastenm├╝ller W, Buschman MD, Schaughency PM, Shirota H, Scarzello AJ, Subleski JJ, Anver MR, Ortaldo JR, Lin F, Reynolds DA, Sanford ME, Kaldis P, Tessarollo L, Klinman DM, Young HA. Hodge DL, et al. Among authors: Coppola V. J Autoimmun. 2014 Sep;53:33-45. doi: 10.1016/j.jaut.2014.02.003. Epub 2014 Feb 28. J Autoimmun. 2014. PMID: 24583068 Free PMC article.
Human HMGA2 protein overexpressed in mice induces precursor T-cell lymphoblastic leukemia.
Efanov A, Zanesi N, Coppola V, Nuovo G, Bolon B, Wernicle-Jameson D, Lagana A, Hansjuerg A, Pichiorri F, Croce CM. Efanov A, et al. Among authors: Coppola V. Blood Cancer J. 2014 Jul 11;4(7):e227. doi: 10.1038/bcj.2014.46. Blood Cancer J. 2014. PMID: 25014774 Free PMC article.
Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II.
Adhikari D, Diril MK, Busayavalasa K, Risal S, Nakagawa S, Lindkvist R, Shen Y, Coppola V, Tessarollo L, Kudo NR, Kaldis P, Liu K. Adhikari D, et al. Among authors: Coppola V. J Cell Biol. 2014 Sep 29;206(7):843-53. doi: 10.1083/jcb.201406033. Epub 2014 Sep 22. J Cell Biol. 2014. PMID: 25246615 Free PMC article.
Cdk2 catalytic activity is essential for meiotic cell division in vivo.
Chauhan S, Diril MK, Lee JH, Bisteau X, Manoharan V, Adhikari D, Ratnacaram CK, Janela B, Noffke J, Ginhoux F, Coppola V, Liu K, Tessarollo L, Kaldis P. Chauhan S, et al. Among authors: Coppola V. Biochem J. 2016 Sep 15;473(18):2783-98. doi: 10.1042/BCJ20160607. Epub 2016 Jul 1. Biochem J. 2016. PMID: 27371320
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