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The Scutellaria baicalensis-Coptis chinensis herb pair ameliorates ulcerative colitis via integrated modulation of the aryl hydrocarbon receptor/NLRP3 inflammasome axis with tryptophan metabolites.
Fang D, Sheng X, Li X, Tan B, Zhang J, Ding K, Kang A. Fang D, et al. Phytomedicine. 2026 Jun;155:158164. doi: 10.1016/j.phymed.2026.158164. Epub 2026 Apr 5. Phytomedicine. 2026. PMID: 41962266
BACKGROUND: The Scutellaria baicalensis Georgi and Coptis chinensis Franch (SC) herb pair constitutes a vital component in many classic formulas exhibited well-documented synergistic therapeutic efficacy against bacterial infections and various inflam …
BACKGROUND: The Scutellaria baicalensis Georgi and Coptis chinensis Franch (SC) herb pair constitutes a vital co …
Chemical Characterization of the Precipitate Found in and Its Effect on Drug Release of the Scutellaria baicalensis-Coptis chinensis Extract.
Kim HY, Kim JH. Kim HY, et al. Chem Biodivers. 2023 Dec;20(12):e202301461. doi: 10.1002/cbdv.202301461. Epub 2023 Nov 30. Chem Biodivers. 2023. PMID: 37961037
Here we explored the composition of the natural precipitate formed from and its effect on drug release of Scutellaria baicalensis-Coptis chinensis paired extract (SCPE). Furthermore, the surface morphology of the SCPE precipitate was also investigated. …
Here we explored the composition of the natural precipitate formed from and its effect on drug release of Scutellaria baicalensis …
Homeostatic regulation of the aryl hydrocarbon receptor-cytochrome P450 1a axis by Scutellaria baicalensis-Coptis chinensis herb pair and its main constituents.
Song M, Sheng X, Zhang J, Li X, Dai Q, Chen Y, Kang A. Song M, et al. J Ethnopharmacol. 2022 Oct 28;297:115545. doi: 10.1016/j.jep.2022.115545. Epub 2022 Jul 15. J Ethnopharmacol. 2022. PMID: 35843411
ETHNOPHARMACOLOGICAL RELEVANCE: Scutellaria baicalensis (SB) and Coptis chinensis (CC) are widely used traditional Chinese medicine (TCM) for "heat-clearing and damp-drying" and "purging fire and detoxifying". ...
ETHNOPHARMACOLOGICAL RELEVANCE: Scutellaria baicalensis (SB) and Coptis chinensis (CC) are widely used tradition …
Primary study on the effects and mechanisms of separate and combined decoctions of Scutellaria baicalensis Georgi - Coptis chinensis Franch extracts in relieving acute alcoholic liver injury in rats.
Shen Y, Zhao Y, Zhong C, Huang H, Yang Z, Wu M, Lu L, Yang R, Ke X. Shen Y, et al. J Ethnopharmacol. 2024 Apr 24;324:117790. doi: 10.1016/j.jep.2024.117790. Epub 2024 Jan 20. J Ethnopharmacol. 2024. PMID: 38253276
ETHNOPHARMACOLOGICAL RELEVANCE: Scutellaria baicalensis Georgi (SBG) and Coptis chinensis Franch (CCF) are traditional herbal medicine pairs used for clearing heat and eliminating dampness, stopping diarrhea, and detoxification. ...Thus, a conflict lie …
ETHNOPHARMACOLOGICAL RELEVANCE: Scutellaria baicalensis Georgi (SBG) and Coptis chinensis Franch (CCF) are tradi …
Composite microneedles loaded with Astragalus membranaceus polysaccharide nanoparticles promote wound healing by curbing the ROS/NF-κB pathway to regulate macrophage polarization.
Liu X, Guo C, Yang W, Wang W, Diao N, Cao M, Cao Y, Wang X, Wang X, Pei H, Jiang Y, Kong M, Chen D. Liu X, et al. Carbohydr Polym. 2024 Dec 1;345:122574. doi: 10.1016/j.carbpol.2024.122574. Epub 2024 Aug 6. Carbohydr Polym. 2024. PMID: 39227108
Among them, loaded with ROS-sensitive nanoparticles of Astragalus polysaccharides (APS) based on effective components baicalein (Bai) and berberine (Ber) from Scutellaria baicalensis (SB) and Coptis chinensis (CC) drugs (APB@Ber). Together, they are co …
Among them, loaded with ROS-sensitive nanoparticles of Astragalus polysaccharides (APS) based on effective components baicalein (Bai) and be …
Harder, better, faster, stronger? Retrospective chart review of adverse events of interactions between adaptogens and antidepressant drugs.
Siwek M, Woroń J, Wrzosek A, Gupało J, Chrobak AA. Siwek M, et al. Front Pharmacol. 2023 Sep 27;14:1271776. doi: 10.3389/fphar.2023.1271776. eCollection 2023. Front Pharmacol. 2023. PMID: 37829299 Free PMC article.
Here, we present the list of adaptogens with the corresponding antidepressants and the side effects caused by their interactions: Withania somnifera: reboxetine (testicle pain and ejaculatory dysfunctions), sertraline (severe diarrhea), escitalopram (myalgia, epigastric pain, nau …
Here, we present the list of adaptogens with the corresponding antidepressants and the side effects caused by their interactions: Withania s …
The Scutellaria-Coptis herb couple and its active small-molecule ingredient wogonoside alleviate cytokine storm by regulating the CD39/NLRP3/GSDMD signaling pathway.
Wang H, Lan Y, Luo L, Xiao Y, Meng X, Zeng Y, Wu J. Wang H, et al. J Ethnopharmacol. 2024 Jul 15;329:118155. doi: 10.1016/j.jep.2024.118155. Epub 2024 Apr 7. J Ethnopharmacol. 2024. PMID: 38593962
ETHNOPHARMACOLOGICAL RELEVANCE: A drug pair is a fundamental aspect of traditional Chinese medicine prescriptions. Scutellaria baicalensis Georgi and Coptis chinensis Franch, commonly used as an herb couple (SBCC), are representative heat-clearing and …
ETHNOPHARMACOLOGICAL RELEVANCE: A drug pair is a fundamental aspect of traditional Chinese medicine prescriptions. Scutellaria bai …
A comparative pharmacological study of three Chinese traditional medicines found Blautia to be the key functional bacterium of Coptis chinensis Franch. and Phellodendri chinensis Cortex against colitis.
Zhan J, Cheng J, Yang Y, Xu X, Lu Z, Li L, Li H, Yang Q, Hu Y, Song Y, Fan Q, Yang E, Liang Q, Sun S, Qiu F, Cao Y, Wu C. Zhan J, et al. Front Pharmacol. 2025 Jun 18;16:1587119. doi: 10.3389/fphar.2025.1587119. eCollection 2025. Front Pharmacol. 2025. PMID: 40606617 Free PMC article.
BACKGROUND: Sanhuang refers to the three cold-natured and bitter-flavored traditional Chinese medicines, namely, Scutellaria baicalensis Georgi (HuangQin, HQ), Coptis chinensis Franch. (HuangLian, HL), and Phellodendri chinensis Cortex (HuangBo, …
BACKGROUND: Sanhuang refers to the three cold-natured and bitter-flavored traditional Chinese medicines, namely, Scutellaria baica …
[Effect of comparability of Coptis chinensis and Scutellaria baicalensis on five sub-enzymatic activities of liver microsomes in rats].
Wei LY, Zhang YJ, Wei BH, Ye J, Yang XY, Sun GX. Wei LY, et al. Zhongguo Zhong Yao Za Zhi. 2013 May;38(9):1426-9. Zhongguo Zhong Yao Za Zhi. 2013. PMID: 23944082 Chinese.
To study the mechanism of metabolic interaction between Coptis chinensis and Scutellaria baicalensis. Rats were given C. chinensis and S. baicalensis for 7 days to produce hepatic microsomal enzyme. ...The compatibility of C. chinensis …
To study the mechanism of metabolic interaction between Coptis chinensis and Scutellaria baicalensis. Rats were …
Involvement of herb-herb interactions in the influences of Radix Scutellaria and Coptis Chinensis on the bioavailability of the anthraquinones form Rhei Rhizoma in rats.
Yan D, Ma B, Shi R, Wang T, Ma Y. Yan D, et al. Eur J Drug Metab Pharmacokinet. 2015 Mar;40(1):103-10. doi: 10.1007/s13318-014-0188-7. Eur J Drug Metab Pharmacokinet. 2015. PMID: 24659524
Xiexin decoction (XXD) is composed of Rhei Rhizoma (DH), Radix Scutellaria (HQ), and Coptis Chinensis (HL). Free anthraquinones in DH are the basic effective constituents in XXD. ...
Xiexin decoction (XXD) is composed of Rhei Rhizoma (DH), Radix Scutellaria (HQ), and Coptis Chinensis (HL). Free anthra …
76 results