Corbin JA - Search Results

1

GRP1 pleckstrin homology domain: activation parameters and novel search mechanism for rare target lipid.

Corbin JA, Dirkx RA, Falke JJ. Corbin JA, et al. Biochemistry. 2004 Dec 28;43(51):16161-73. doi: 10.1021/bi049017a. Biochemistry. 2004. PMID: 15610010 Free PMC article.

2

Membrane docking geometry of GRP1 PH domain bound to a target lipid bilayer: an EPR site-directed spin-labeling and relaxation study.

Chen HC, Ziemba BP, Landgraf KE, Corbin JA, Falke JJ. Chen HC, et al. Among authors: corbin ja. PLoS One. 2012;7(3):e33640. doi: 10.1371/journal.pone.0033640. Epub 2012 Mar 30. PLoS One. 2012. PMID: 22479423 Free PMC article.

3

Mechanism of specific membrane targeting by C2 domains: localized pools of target lipids enhance Ca2+ affinity.

Corbin JA, Evans JH, Landgraf KE, Falke JJ. Corbin JA, et al. Biochemistry. 2007 Apr 10;46(14):4322-36. doi: 10.1021/bi062140c. Epub 2007 Mar 17. Biochemistry. 2007. PMID: 17367165 Free PMC article.

4

Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinity.

Corbin JA, Bhaskar V, Goldfine ID, Bedinger DH, Lau A, Michelson K, Gross LM, Maddux BA, Kuan HF, Tran C, Lao L, Handa M, Watson SR, Narasimha AJ, Zhu S, Levy R, Webster L, Wijesuriya SD, Liu N, Wu X, Chemla-Vogel D, Lee SR, Wong S, Wilcock D, White ML. Corbin JA, et al. PLoS One. 2014 Feb 12;9(2):e88684. doi: 10.1371/journal.pone.0088684. eCollection 2014. PLoS One. 2014. PMID: 24533136 Free PMC article.

5

XMetA, an allosteric monoclonal antibody to the insulin receptor, improves glycaemic control in mice with diet-induced obesity.

Bhaskar V, Lau A, Goldfine ID, Narasimha AJ, Gross LM, Wong S, Cheung B, White ML, Corbin JA. Bhaskar V, et al. Among authors: corbin ja. Diabetes Obes Metab. 2013 Mar;15(3):272-5. doi: 10.1111/dom.12019. Epub 2012 Oct 29. Diabetes Obes Metab. 2013. PMID: 23039274

6

An allosteric antibody to the leptin receptor reduces body weight and reverses the diabetic phenotype in the Lep(ob) /Lep(ob) mouse.

Bhaskar V, Goldfine ID, Gerstner R, Michelson K, Tran C, Nonet G, Bohmann D, Pongo E, Zhao J, Horwitz AH, Takeuchi T, White M, Corbin JA. Bhaskar V, et al. Among authors: corbin ja. Obesity (Silver Spring). 2016 Aug;24(8):1687-94. doi: 10.1002/oby.21539. Epub 2016 Jun 21. Obesity (Silver Spring). 2016. PMID: 27330016 Free article.

7

Differential pathway coupling of the activated insulin receptor drives signaling selectivity by XMetA, an allosteric partial agonist antibody.

Bedinger DH, Goldfine ID, Corbin JA, Roell MK, Adams SH. Bedinger DH, et al. Among authors: corbin ja. J Pharmacol Exp Ther. 2015 Apr;353(1):35-43. doi: 10.1124/jpet.114.221309. Epub 2015 Jan 22. J Pharmacol Exp Ther. 2015. PMID: 25613982

8

Selective allosteric antibodies to the insulin receptor for the treatment of hyperglycemic and hypoglycemic disorders.

Issafras H, Bedinger DH, Corbin JA, Goldfine ID, Bhaskar V, White ML, Rubin P, Scannon PJ. Issafras H, et al. Among authors: corbin ja. J Diabetes Sci Technol. 2014 Jul;8(4):865-73. doi: 10.1177/1932296814529886. Epub 2014 Apr 7. J Diabetes Sci Technol. 2014. PMID: 24876415 Free PMC article.

9

Inhibition of insulin receptor function by a human, allosteric monoclonal antibody: a potential new approach for the treatment of hyperinsulinemic hypoglycemia.

Corbin JA, Bhaskar V, Goldfine ID, Issafras H, Bedinger DH, Lau A, Michelson K, Gross LM, Maddux BA, Kuan HF, Tran C, Lao L, Handa M, Watson SR, Narasimha AJ, Zhu S, Levy R, Webster L, Wijesuriya SD, Liu N, Wu X, Chemla-Vogel D, Lee SR, Wong S, Wilcock D, Rubin P, White ML. Corbin JA, et al. MAbs. 2014 Jan-Feb;6(1):262-72. doi: 10.4161/mabs.26871. MAbs. 2014. PMID: 24423625 Free PMC article.

10

Detailed mechanistic analysis of gevokizumab, an allosteric anti-IL-1β antibody with differential receptor-modulating properties.

Issafras H, Corbin JA, Goldfine ID, Roell MK. Issafras H, et al. Among authors: corbin ja. J Pharmacol Exp Ther. 2014 Jan;348(1):202-15. doi: 10.1124/jpet.113.205443. Epub 2013 Nov 5. J Pharmacol Exp Ther. 2014. PMID: 24194526 Free PMC article.

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