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Effects of androgens on insulin action in women: is androgen excess a component of female metabolic syndrome?
Corbould A. Corbould A. Diabetes Metab Res Rev. 2008 Oct;24(7):520-32. doi: 10.1002/dmrr.872. Diabetes Metab Res Rev. 2008. PMID: 18615851 Review.
The adipose cell lineage is not intrinsically insulin resistant in polycystic ovary syndrome.
Corbould A, Dunaif A. Corbould A, et al. Metabolism. 2007 May;56(5):716-22. doi: 10.1016/j.metabol.2006.12.021. Metabolism. 2007. PMID: 17445549 Free PMC article.
Selective resistance to the effects of insulin on glucose metabolism in skeletal muscle and adipose tissue is a key feature of polycystic ovary syndrome (PCOS). ...
Selective resistance to the effects of insulin on glucose metabolism in skeletal muscle and adipose tissue is a key feature of polycy …
Enhanced mitogenic signaling in skeletal muscle of women with polycystic ovary syndrome.
Corbould A, Zhao H, Mirzoeva S, Aird F, Dunaif A. Corbould A, et al. Diabetes. 2006 Mar;55(3):751-9. doi: 10.2337/diabetes.55.03.06.db05-0453. Diabetes. 2006. PMID: 16505239
Insulin resistance in polycystic ovary syndrome (PCOS) results from a postbinding defect in signaling. Insulin receptor and insulin receptor substrate (IRS)-1 serine hyperphosphorylation by an unidentified kinase(s) contributes to this defect. ...We conclude that in PCOS s …
Insulin resistance in polycystic ovary syndrome (PCOS) results from a postbinding defect in signaling. Insulin receptor and insulin r …
Regulation of adenosine 5',monophosphate-activated protein kinase and lipogenesis by androgens contributes to visceral obesity in an estrogen-deficient state.
McInnes KJ, Corbould A, Simpson ER, Jones ME. McInnes KJ, et al. Among authors: corbould a. Endocrinology. 2006 Dec;147(12):5907-13. doi: 10.1210/en.2006-0879. Epub 2006 Sep 21. Endocrinology. 2006. PMID: 16990341
In 3T3-L1 cells, DHT decreased phosphorylation of AMPK in a dose-dependent manner. In addition, DHT increased the expression of lipogenic genes (fatty acid synthase, sterol regulatory element binding protein-2, and lipoprotein lipase) in visceral fat. ...
In 3T3-L1 cells, DHT decreased phosphorylation of AMPK in a dose-dependent manner. In addition, DHT increased the expression of lipog …
Interrelationships of serum androgens, omental adipose tissue metabolism, and nonalcoholic fatty liver disease in obese premenopausal women.
Corbould A, Bhathal PS, Dixon JB, O'Brien PE. Corbould A, et al. Metab Syndr Relat Disord. 2014 Aug;12(6):311-9. doi: 10.1089/met.2013.0105. Epub 2014 May 12. Metab Syndr Relat Disord. 2014. PMID: 24819229
Chronic testosterone treatment induces selective insulin resistance in subcutaneous adipocytes of women.
Corbould A. Corbould A. J Endocrinol. 2007 Mar;192(3):585-94. doi: 10.1677/joe.1.07070. J Endocrinol. 2007. PMID: 17332526
Adipose tissue plays a central role in determining whole body insulin sensitivity. Several aspects of adipose cell function are regulated by androgens. ...
Adipose tissue plays a central role in determining whole body insulin sensitivity. Several aspects of adipose cell function are regul …
Insulin resistance in skeletal muscle and adipose tissue in polycystic ovary syndrome: are the molecular mechanisms distinct from type 2 diabetes?
Corbould A. Corbould A. Panminerva Med. 2008 Dec;50(4):279-94. Panminerva Med. 2008. PMID: 19078869 Review.
Effects of spironolactone on glucose transport and interleukin-6 secretion in adipose cells of women.
Corbould A. Corbould A. Horm Metab Res. 2007 Dec;39(12):915-8. doi: 10.1055/s-2007-993156. Horm Metab Res. 2007. PMID: 18075971
Spironolactone may have a novel role in increasing glucose uptake into adipose cells and attenuating adipose tissue inflammation, with implications for management of metabolic syndrome....
Spironolactone may have a novel role in increasing glucose uptake into adipose cells and attenuating adipose tissue inflammation, wit …
Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling.
Corbould A, Kim YB, Youngren JF, Pender C, Kahn BB, Lee A, Dunaif A. Corbould A, et al. Am J Physiol Endocrinol Metab. 2005 May;288(5):E1047-54. doi: 10.1152/ajpendo.00361.2004. Epub 2004 Dec 21. Am J Physiol Endocrinol Metab. 2005. PMID: 15613682
Phosphorylation of IRS-1 on Ser312, a key regulatory site, was significantly increased in PCOS, which may have contributed to this signaling defect. ...These abnormalities differ from those reported in other insulin resistant states consistent with the hypothesis that PCOS …
Phosphorylation of IRS-1 on Ser312, a key regulatory site, was significantly increased in PCOS, which may have contributed to this si …
Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways.
Rui L, Aguirre V, Kim JK, Shulman GI, Lee A, Corbould A, Dunaif A, White MF. Rui L, et al. Among authors: corbould a. J Clin Invest. 2001 Jan;107(2):181-9. doi: 10.1172/JCI10934. J Clin Invest. 2001. PMID: 11160134 Free PMC article.
To monitor phosphorylation of Ser307 in various cell and tissue backgrounds, we prepared a phosphospecific polyclonal antibody designated alphapSer307. ...
To monitor phosphorylation of Ser307 in various cell and tissue backgrounds, we prepared a phosphospecific polyclonal antibody design …
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