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69 results
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Non-homologous DNA increases gene disruption efficiency by altering DNA repair outcomes.
Richardson CD, Ray GJ, Bray NL, Corn JE. Richardson CD, et al. Among authors: corn je. Nat Commun. 2016 Aug 17;7:12463. doi: 10.1038/ncomms12463. Nat Commun. 2016. PMID: 27530320 Free PMC article.
Identification of a DNA primase template tracking site redefines the geometry of primer synthesis.
Corn JE, Pelton JG, Berger JM. Corn JE, et al. Nat Struct Mol Biol. 2008 Feb;15(2):163-9. doi: 10.1038/nsmb.1373. Epub 2008 Jan 13. Nat Struct Mol Biol. 2008. PMID: 18193061
THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves.
Sabogal A, Lyubimov AY, Corn JE, Berger JM, Rio DC. Sabogal A, et al. Among authors: corn je. Nat Struct Mol Biol. 2010 Jan;17(1):117-23. doi: 10.1038/nsmb.1742. Epub 2009 Dec 13. Nat Struct Mol Biol. 2010. PMID: 20010837 Free PMC article.
Biotechnology. A prudent path forward for genomic engineering and germline gene modification.
Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, Sternberg SH, Weissman JS, Yamamoto KR. Baltimore D, et al. Among authors: corn je. Science. 2015 Apr 3;348(6230):36-8. doi: 10.1126/science.aab1028. Epub 2015 Mar 19. Science. 2015. PMID: 25791083 Free PMC article.
CRISPR germline engineering--the community speaks.
Bosley KS, Botchan M, Bredenoord AL, Carroll D, Charo RA, Charpentier E, Cohen R, Corn J, Doudna J, Feng G, Greely HT, Isasi R, Ji W, Kim JS, Knoppers B, Lanphier E, Li J, Lovell-Badge R, Martin GS, Moreno J, Naldini L, Pera M, Perry AC, Venter JC, Zhang F, Zhou Q. Bosley KS, et al. Nat Biotechnol. 2015 May;33(5):478-86. doi: 10.1038/nbt.3227. Nat Biotechnol. 2015. PMID: 25965754 No abstract available.
Co-opting CRISPR to deliver functional RNAs.
Lin PC, Corn JE. Lin PC, et al. Among authors: corn je. Nat Methods. 2015 Jul;12(7):613-4. doi: 10.1038/nmeth.3452. Nat Methods. 2015. PMID: 26125593 No abstract available.
Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA.
Richardson CD, Ray GJ, DeWitt MA, Curie GL, Corn JE. Richardson CD, et al. Among authors: corn je. Nat Biotechnol. 2016 Mar;34(3):339-44. doi: 10.1038/nbt.3481. Epub 2016 Jan 20. Nat Biotechnol. 2016. PMID: 26789497
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.
Horlbeck MA, Gilbert LA, Villalta JE, Adamson B, Pak RA, Chen Y, Fields AP, Park CY, Corn JE, Kampmann M, Weissman JS. Horlbeck MA, et al. Among authors: corn je. Elife. 2016 Sep 23;5:e19760. doi: 10.7554/eLife.19760. Elife. 2016. PMID: 27661255 Free PMC article.
Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells.
DeWitt MA, Magis W, Bray NL, Wang T, Berman JR, Urbinati F, Heo SJ, Mitros T, Muñoz DP, Boffelli D, Kohn DB, Walters MC, Carroll D, Martin DI, Corn JE. DeWitt MA, et al. Among authors: corn je. Sci Transl Med. 2016 Oct 12;8(360):360ra134. doi: 10.1126/scitranslmed.aaf9336. Sci Transl Med. 2016. PMID: 27733558 Free PMC article.
Cornerstones of CRISPR-Cas in drug discovery and therapy.
Fellmann C, Gowen BG, Lin PC, Doudna JA, Corn JE. Fellmann C, et al. Among authors: corn je. Nat Rev Drug Discov. 2017 Feb;16(2):89-100. doi: 10.1038/nrd.2016.238. Epub 2016 Dec 23. Nat Rev Drug Discov. 2017. PMID: 28008168 Free PMC article. Review.
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