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Biotechnology. A prudent path forward for genomic engineering and germline gene modification.
Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, Sternberg SH, Weissman JS, Yamamoto KR. Baltimore D, et al. Science. 2015 Apr 3;348(6230):36-8. doi: 10.1126/science.aab1028. Epub 2015 Mar 19. Science. 2015. PMID: 25791083 Free PMC article.
CRISPR germline engineering--the community speaks.
Bosley KS, Botchan M, Bredenoord AL, Carroll D, Charo RA, Charpentier E, Cohen R, Corn J, Doudna J, Feng G, Greely HT, Isasi R, Ji W, Kim JS, Knoppers B, Lanphier E, Li J, Lovell-Badge R, Martin GS, Moreno J, Naldini L, Pera M, Perry AC, Venter JC, Zhang F, Zhou Q. Bosley KS, et al. Nat Biotechnol. 2015 May;33(5):478-86. doi: 10.1038/nbt.3227. Nat Biotechnol. 2015. PMID: 25965754 No abstract available.
Co-opting CRISPR to deliver functional RNAs.
Lin PC, Corn JE. Lin PC, et al. Nat Methods. 2015 Jul;12(7):613-4. doi: 10.1038/nmeth.3452. Nat Methods. 2015. PMID: 26125593 No abstract available.
Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells.
DeWitt MA, Magis W, Bray NL, Wang T, Berman JR, Urbinati F, Heo SJ, Mitros T, Muñoz DP, Boffelli D, Kohn DB, Walters MC, Carroll D, Martin DI, Corn JE. DeWitt MA, et al. Sci Transl Med. 2016 Oct 12;8(360):360ra134. doi: 10.1126/scitranslmed.aaf9336. Sci Transl Med. 2016. PMID: 27733558 Free PMC article.
Cornerstones of CRISPR-Cas in drug discovery and therapy.
Fellmann C, Gowen BG, Lin PC, Doudna JA, Corn JE. Fellmann C, et al. Nat Rev Drug Discov. 2017 Feb;16(2):89-100. doi: 10.1038/nrd.2016.238. Epub 2016 Dec 23. Nat Rev Drug Discov. 2017. PMID: 28008168 Free PMC article. Review.
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