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TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.
Fiers W, Beyaert R, Boone E, Cornelis S, Declercq W, Decoster E, Denecker G, Depuydt B, De Valck D, De Wilde G, Goossens V, Grooten J, Haegeman G, Heyninck K, Penning L, Plaisance S, Vancompernolle K, Van Criekinge W, Vandenabeele P, Vanden Berghe W, Van de Craen M, Vandevoorde V, Vercammen D. Fiers W, et al. Among authors: cornelis s. J Inflamm. 1995-1996;47(1-2):67-75. J Inflamm. 1995. PMID: 8913931 Review.
Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria.
Wirawan E, Vande Walle L, Kersse K, Cornelis S, Claerhout S, Vanoverberghe I, Roelandt R, De Rycke R, Verspurten J, Declercq W, Agostinis P, Vanden Berghe T, Lippens S, Vandenabeele P. Wirawan E, et al. Among authors: cornelis s. Cell Death Dis. 2010;1(1):e18. doi: 10.1038/cddis.2009.16. Cell Death Dis. 2010. PMID: 21364619 Free PMC article.
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