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A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex.
Patel A, Vought VE, Dharmarajan V, Cosgrove MS. Patel A, et al. Among authors: cosgrove ms. J Biol Chem. 2008 Nov 21;283(47):32162-75. doi: 10.1074/jbc.M806317200. Epub 2008 Oct 1. J Biol Chem. 2008. PMID: 18829457
Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.
Alicea-Velázquez NL, Shinsky SA, Loh DM, Lee JH, Skalnik DG, Cosgrove MS. Alicea-Velázquez NL, et al. Among authors: cosgrove ms. J Biol Chem. 2016 Oct 21;291(43):22357-22372. doi: 10.1074/jbc.M116.752626. Epub 2016 Aug 25. J Biol Chem. 2016. PMID: 27563068 Free PMC article.
Mgm101 is a Rad52-related protein required for mitochondrial DNA recombination.
Mbantenkhu M, Wang X, Nardozzi JD, Wilkens S, Hoffman E, Patel A, Cosgrove MS, Chen XJ. Mbantenkhu M, et al. Among authors: cosgrove ms. J Biol Chem. 2011 Dec 9;286(49):42360-70. doi: 10.1074/jbc.M111.307512. Epub 2011 Oct 25. J Biol Chem. 2011. PMID: 22027892 Free PMC article.
Myosin5a tail associates directly with Rab3A-containing compartments in neurons.
Wöllert T, Patel A, Lee YL, Provance DW Jr, Vought VE, Cosgrove MS, Mercer JA, Langford GM. Wöllert T, et al. Among authors: cosgrove ms. J Biol Chem. 2011 Apr 22;286(16):14352-61. doi: 10.1074/jbc.M110.187286. Epub 2011 Feb 23. J Biol Chem. 2011. PMID: 21349835 Free PMC article.
Unique Role of the WD-40 Repeat Protein 5 (WDR5) Subunit within the Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Complex.
Shinsky SA, Cosgrove MS. Shinsky SA, et al. Among authors: cosgrove ms. J Biol Chem. 2015 Oct 23;290(43):25819-33. doi: 10.1074/jbc.M115.684142. Epub 2015 Aug 31. J Biol Chem. 2015. PMID: 26324722 Free PMC article.
A non-active-site SET domain surface crucial for the interaction of MLL1 and the RbBP5/Ash2L heterodimer within MLL family core complexes.
Shinsky SA, Hu M, Vought VE, Ng SB, Bamshad MJ, Shendure J, Cosgrove MS. Shinsky SA, et al. Among authors: cosgrove ms. J Mol Biol. 2014 Jun 12;426(12):2283-99. doi: 10.1016/j.jmb.2014.03.011. Epub 2014 Mar 27. J Mol Biol. 2014. PMID: 24680668 Free PMC article.
Allosteric activation of the phosphoinositide phosphatase Sac1 by anionic phospholipids.
Zhong S, Hsu F, Stefan CJ, Wu X, Patel A, Cosgrove MS, Mao Y. Zhong S, et al. Among authors: cosgrove ms. Biochemistry. 2012 Apr 17;51(15):3170-7. doi: 10.1021/bi300086c. Epub 2012 Apr 3. Biochemistry. 2012. PMID: 22452743 Free PMC article.
The Bin3 RNA methyltransferase targets 7SK RNA to control transcription and translation.
Cosgrove MS, Ding Y, Rennie WA, Lane MJ, Hanes SD. Cosgrove MS, et al. Wiley Interdiscip Rev RNA. 2012 Sep-Oct;3(5):633-47. doi: 10.1002/wrna.1123. Epub 2012 Jun 27. Wiley Interdiscip Rev RNA. 2012. PMID: 22740346 Free PMC article. Review.
Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation.
Patel A, Vought VE, Swatkoski S, Viggiano S, Howard B, Dharmarajan V, Monteith KE, Kupakuwana G, Namitz KE, Shinsky SA, Cotter RJ, Cosgrove MS. Patel A, et al. Among authors: cosgrove ms. J Biol Chem. 2014 Jan 10;289(2):868-84. doi: 10.1074/jbc.M113.501064. Epub 2013 Nov 14. J Biol Chem. 2014. PMID: 24235145 Free PMC article.
Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.
Shinsky SA, Monteith KE, Viggiano S, Cosgrove MS. Shinsky SA, et al. Among authors: cosgrove ms. J Biol Chem. 2015 Mar 6;290(10):6361-75. doi: 10.1074/jbc.M114.627646. Epub 2015 Jan 5. J Biol Chem. 2015. PMID: 25561738 Free PMC article.
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