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ICI 182,780 penetrates brain and hypothalamic tissue and has functional effects in the brain after systemic dosing.
Alfinito PD, Chen X, Atherton J, Cosmi S, Deecher DC. Alfinito PD, et al. Among authors: cosmi s. Endocrinology. 2008 Oct;149(10):5219-26. doi: 10.1210/en.2008-0532. Epub 2008 Jul 3. Endocrinology. 2008. PMID: 18599545
Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.
Mahaney PE, Gavrin LK, Trybulski EJ, Stack GP, Vu TA, Cohn ST, Ye F, Belardi JK, Santilli AA, Sabatucci JP, Leiter J, Johnston GH, Bray JA, Burroughs KD, Cosmi SA, Leventhal L, Koury EJ, Zhang Y, Mugford CA, Ho DM, Rosenzweig-Lipson SJ, Platt B, Smith VA, Deecher DC. Mahaney PE, et al. J Med Chem. 2008 Jul 10;51(13):4038-49. doi: 10.1021/jm8002262. Epub 2008 Jun 17. J Med Chem. 2008. PMID: 18557608
Simultaneous telemetric monitoring of tail-skin and core body temperature in a rat model of thermoregulatory dysfunction.
Cosmi S, Pawlyk AC, Alfinito PD, Roman J, Zhou T, Deecher DC. Cosmi S, et al. J Neurosci Methods. 2009 Apr 15;178(2):270-5. doi: 10.1016/j.jneumeth.2008.12.013. Epub 2008 Dec 24. J Neurosci Methods. 2009. PMID: 19135085
The role of the selective serotonin reuptake inhibitor fluoxetine in temperature regulation in ovariectomized rat models.
Maswood N, Cosmi S, Alfinito PD, Leventhal L, Deecher DC. Maswood N, et al. Among authors: cosmi s. Neuroendocrinology. 2006;84(5):330-8. doi: 10.1159/000098322. Epub 2006 Dec 28. Neuroendocrinology. 2006. PMID: 17192701
Alleviation of thermoregulatory dysfunction with the new serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized rodent models.
Deecher DC, Alfinito PD, Leventhal L, Cosmi S, Johnston GH, Merchenthaler I, Winneker R. Deecher DC, et al. Among authors: cosmi s. Endocrinology. 2007 Mar;148(3):1376-83. doi: 10.1210/en.2006-1163. Epub 2006 Nov 22. Endocrinology. 2007. PMID: 17122073
Effects of the 5-HT2A antagonist mirtazapine in rat models of thermoregulation.
Pawlyk AC, Cosmi S, Alfinito PD, Maswood N, Deecher DC. Pawlyk AC, et al. Among authors: cosmi s. Brain Res. 2006 Dec 6;1123(1):135-44. doi: 10.1016/j.brainres.2006.09.050. Epub 2006 Oct 24. Brain Res. 2006. PMID: 17067560
Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction.
Sipe K, Leventhal L, Burroughs K, Cosmi S, Johnston GH, Deecher DC. Sipe K, et al. Among authors: cosmi s. Brain Res. 2004 Dec 3;1028(2):191-202. doi: 10.1016/j.brainres.2004.09.012. Brain Res. 2004. PMID: 15527744
Effect of calcium channel modulators on temperature regulation in ovariectomized rats.
Leventhal L, Cosmi S, Deecher D. Leventhal L, et al. Among authors: cosmi s. Pharmacol Biochem Behav. 2005 Mar;80(3):511-20. doi: 10.1016/j.pbb.2005.01.005. Pharmacol Biochem Behav. 2005. PMID: 15740794
Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231).
O'Neill DJ, Adedoyin A, Alfinito PD, Bray JA, Cosmi S, Deecher DC, Fensome A, Harrison J, Leventhal L, Mann C, McComas CC, Sullivan NR, Spangler TB, Uveges AJ, Trybulski EJ, Whiteside GT, Zhang P. O'Neill DJ, et al. Among authors: cosmi s. J Med Chem. 2010 Jun 10;53(11):4511-21. doi: 10.1021/jm100053t. J Med Chem. 2010. PMID: 20462211
1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors.
Vu AT, Cohn ST, Zhang P, Kim CY, Mahaney PE, Bray JA, Johnston GH, Koury EJ, Cosmi SA, Deecher DC, Smith VA, Harrison JE, Leventhal L, Whiteside GT, Kennedy JD, Trybulski EJ. Vu AT, et al. Among authors: cosmi sa. J Med Chem. 2010 Mar 11;53(5):2051-62. doi: 10.1021/jm901559e. J Med Chem. 2010. PMID: 20131864
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