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Neutrophils in the activation and regulation of innate and adaptive immunity.
Mantovani A, Cassatella MA, Costantini C, Jaillon S. Mantovani A, et al. Nat Rev Immunol. 2011 Jul 25;11(8):519-31. doi: 10.1038/nri3024. Nat Rev Immunol. 2011. PMID: 21785456 Review.
Evidence for a cross-talk between human neutrophils and Th17 cells.
Pelletier M, Maggi L, Micheletti A, Lazzeri E, Tamassia N, Costantini C, Cosmi L, Lunardi C, Annunziato F, Romagnani S, Cassatella MA. Pelletier M, et al. Blood. 2010 Jan 14;115(2):335-43. doi: 10.1182/blood-2009-04-216085. Epub 2009 Nov 4. Blood. 2010. PMID: 19890092
Neutrophil activation and survival are modulated by interaction with NK cells.
Costantini C, Micheletti A, Calzetti F, Perbellini O, Pizzolo G, Cassatella MA. Costantini C, et al. Int Immunol. 2010 Oct;22(10):827-38. doi: 10.1093/intimm/dxq434. Epub 2010 Aug 25. Int Immunol. 2010. PMID: 20739460
Human neutrophils interact with both 6-sulfo LacNAc+ DC and NK cells to amplify NK-derived IFN{gamma}: role of CD18, ICAM-1, and ICAM-3.
Costantini C, Calzetti F, Perbellini O, Micheletti A, Scarponi C, Lonardi S, Pelletier M, Schakel K, Pizzolo G, Facchetti F, Vermi W, Albanesi C, Cassatella MA. Costantini C, et al. Blood. 2011 Feb 3;117(5):1677-86. doi: 10.1182/blood-2010-06-287243. Epub 2010 Nov 22. Blood. 2011. PMID: 21098395
On the potential involvement of CD11d in co-stimulating the production of interferon-γ by natural killer cells upon interaction with neutrophils via intercellular adhesion molecule-3.
Costantini C, Micheletti A, Calzetti F, Perbellini O, Tamassia N, Albanesi C, Vermi W, Cassatella MA. Costantini C, et al. Haematologica. 2011 Oct;96(10):1543-7. doi: 10.3324/haematol.2011.044578. Epub 2011 Jun 28. Haematologica. 2011. PMID: 21712539 Free PMC article.
IFN-β expression is directly activated in human neutrophils transfected with plasmid DNA and is further increased via TLR-4-mediated signaling.
Tamassia N, Bazzoni F, Le Moigne V, Calzetti F, Masala C, Grisendi G, Bussmeyer U, Scutera S, De Gironcoli M, Costantini C, Musso T, Cassatella MA. Tamassia N, et al. J Immunol. 2012 Aug 1;189(3):1500-9. doi: 10.4049/jimmunol.1102985. Epub 2012 Jun 22. J Immunol. 2012. PMID: 22730532
Because neutrophils do not express protein kinase C ε, a molecule recently reported as essential for initiating the MyD88-independent/TRIF-dependent pathway, we optimized an electroporation method to transfect PKCε into neutrophils with very high efficiency. ...
Because neutrophils do not express protein kinase C ε, a molecule recently reported as essential for initiating the MyD88-independent …
Cellular proteostasis: a new twist in the action of thymosin α1.
Stincardini C, Renga G, Villella V, Pariano M, Oikonomou V, Borghi M, Bellet MM, Sforna L, Costantini C, Goldstein AL, Garaci E, Romani L. Stincardini C, et al. Expert Opin Biol Ther. 2018 Jul;18(sup1):43-48. doi: 10.1080/14712598.2018.1484103. Expert Opin Biol Ther. 2018. PMID: 30063867 Review.
Characterization of the signaling pathway downstream p75 neurotrophin receptor involved in beta-amyloid peptide-dependent cell death.
Costantini C, Rossi F, Formaggio E, Bernardoni R, Cecconi D, Della-Bianca V. Costantini C, et al. J Mol Neurosci. 2005;25(2):141-56. doi: 10.1385/JMN:25:2:141. J Mol Neurosci. 2005. PMID: 15784962
By using a neuroblastoma cell line devoid of neurotrophin receptors and engineered to express either a full-length or a death domain (DD)-truncated form of p75NTR, we demonstrated that Abeta peptide activates the mitogen-activated protein kinases (MAPKs) p38 and c-Jun N-te …
By using a neuroblastoma cell line devoid of neurotrophin receptors and engineered to express either a full-length or a death domain (DD)-tr …
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