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Molecular Insights into the Local Anesthetic Receptor within Voltage-Gated Sodium Channels Using Hydroxylated Analogs of Mexiletine.
Front Pharmacol. 2012 Feb 15;3:17. doi: 10.3389/fphar.2012.00017. eCollection 2012.
Front Pharmacol. 2012.
PMID: 22403541
Free PMC article.
Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide.
Desaphy JF, Dipalma A, Costanza T, Bruno C, Lentini G, Franchini C, George A, Conte Camerino D.
Desaphy JF, et al. Among authors: costanza t.
Br J Pharmacol. 2010 Jul;160(6):1521-33. doi: 10.1111/j.1476-5381.2010.00816.x.
Br J Pharmacol. 2010.
PMID: 20590641
Free PMC article.
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Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity.
Catalano A, Carocci A, Cavalluzzi MM, Di Mola A, Lentini G, Lovece A, Dipalma A, Costanza T, Desaphy JF, Conte Camerino D, Franchini C.
Catalano A, et al. Among authors: costanza t.
Arch Pharm (Weinheim). 2010 Jun;343(6):325-32. doi: 10.1002/ardp.200900218.
Arch Pharm (Weinheim). 2010.
PMID: 20509146
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Molecular dissection of lubeluzole use-dependent block of voltage-gated sodium channels discloses new therapeutic potentials.
Desaphy JF, Carbonara R, Costanza T, Lentini G, Cavalluzzi MM, Bruno C, Franchini C, Camerino DC.
Desaphy JF, et al. Among authors: costanza t.
Mol Pharmacol. 2013 Feb;83(2):406-15. doi: 10.1124/mol.112.080804. Epub 2012 Nov 21.
Mol Pharmacol. 2013.
PMID: 23175529
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Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine.
Desaphy JF, Dipalma A, De Bellis M, Costanza T, Gaudioso C, Delmas P, George AL Jr, Camerino DC.
Desaphy JF, et al. Among authors: costanza t.
Pain. 2009 Apr;142(3):225-235. doi: 10.1016/j.pain.2009.01.010. Epub 2009 Feb 12.
Pain. 2009.
PMID: 19217209
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In vivo evaluation of antimyotonic efficacy of β-adrenergic drugs in a rat model of myotonia.
Desaphy JF, Costanza T, Carbonara R, Conte Camerino D.
Desaphy JF, et al. Among authors: costanza t.
Neuropharmacology. 2013 Feb;65:21-7. doi: 10.1016/j.neuropharm.2012.09.006. Epub 2012 Sep 18.
Neuropharmacology. 2013.
PMID: 23000075
Free PMC article.
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Preclinical evaluation of marketed sodium channel blockers in a rat model of myotonia discloses promising antimyotonic drugs.
Desaphy JF, Carbonara R, Costanza T, Conte Camerino D.
Desaphy JF, et al. Among authors: costanza t.
Exp Neurol. 2014 May;255(100):96-102. doi: 10.1016/j.expneurol.2014.02.023. Epub 2014 Mar 5.
Exp Neurol. 2014.
PMID: 24613829
Free PMC article.
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