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Human telomeres that carry an integrated copy of human herpesvirus 6 are often short and unstable, facilitating release of the viral genome from the chromosome.
Huang Y, Hidalgo-Bravo A, Zhang E, Cotton VE, Mendez-Bermudez A, Wig G, Medina-Calzada Z, Neumann R, Jeffreys AJ, Winney B, Wilson JF, Clark DA, Dyer MJ, Royle NJ. Huang Y, et al. Among authors: cotton ve. Nucleic Acids Res. 2014 Jan;42(1):315-27. doi: 10.1093/nar/gkt840. Epub 2013 Sep 19. Nucleic Acids Res. 2014. PMID: 24057213 Free PMC article.
Telomere length maintenance--an ALTernative mechanism.
Royle NJ, Foxon J, Jeyapalan JN, Mendez-Bermudez A, Novo CL, Williams J, Cotton VE. Royle NJ, et al. Among authors: cotton ve. Cytogenet Genome Res. 2008;122(3-4):281-91. doi: 10.1159/000167814. Epub 2009 Jan 30. Cytogenet Genome Res. 2008. PMID: 19188697 Review.
The role of recombination in telomere length maintenance.
Royle NJ, Méndez-Bermúdez A, Gravani A, Novo C, Foxon J, Williams J, Cotton V, Hidalgo A. Royle NJ, et al. Biochem Soc Trans. 2009 Jun;37(Pt 3):589-95. doi: 10.1042/BST0370589. Biochem Soc Trans. 2009. PMID: 19442255
HHV-8-unrelated primary effusion-like lymphoma associated with clonal loss of inherited chromosomally-integrated human herpesvirus-6A from the telomere of chromosome 19q.
Zhang E, Cotton VE, Hidalgo-Bravo A, Huang Y, Bell AJ, Jarrett RF, Wilkie GS, Davison AJ, Nacheva EP, Siebert R, Majid A, Kelpanides I, Jayne S, Dyer MJ, Royle NJ. Zhang E, et al. Among authors: cotton ve. Sci Rep. 2016 Mar 7;6:22730. doi: 10.1038/srep22730. Sci Rep. 2016. PMID: 26947392 Free PMC article.
Inherited Chromosomally Integrated Human Herpesvirus 6 Genomes Are Ancient, Intact, and Potentially Able To Reactivate from Telomeres.
Zhang E, Bell AJ, Wilkie GS, Suárez NM, Batini C, Veal CD, Armendáriz-Castillo I, Neumann R, Cotton VE, Huang Y, Porteous DJ, Jarrett RF, Davison AJ, Royle NJ. Zhang E, et al. Among authors: cotton ve. J Virol. 2017 Oct 27;91(22):e01137-17. doi: 10.1128/JVI.01137-17. Print 2017 Nov 15. J Virol. 2017. PMID: 28835501 Free PMC article. Clinical Trial.
13 results